Recombinant Full Length Human IL3RA Protein, C-Flag-tagged

• Cat.No.: IL3RA-702HFL
• Product Overview: Recombinant Full Length Human IL3RA Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 41.2 kDa
• AA Sequence: MVLLWLTLLLIALPCLLQTKEDPNP PITNLRMKAKAQQLTWDLNRNVTDI ECVKDADYSMPAVNNSYCQF GAISLCEVTNYTVRVANPPFSTWIL FPENSGKPWAGAENLTCWIHDVDFL SCSWAVGPGAPADVQYDLYL NVANRRQQYECLHYKTDAQGTRIGC RFDDISRLSSGSQSSHILVRGRSAA FGIPCTDKFVVFSQIEILTP PNMTAKCNKTHSFMHWKMRSHFNRK FRYELQIQKRMQPVITEQVRDRTSF QLLNPGTYTVQIRARERVYE FLSAWSTPQRFECDQEEGANTRAWR TSLLIALGTLLALVCVFVICRRYLV MQRLFPRIPHMKDPIGDSFQ
  NDKLVVWEAGKAGLEECLVTEVQVV QKTTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

Gene Information

• Gene Name: IL3RA interleukin 3 receptor subunit alpha [ Homo sapiens (human) ]
• Official Symbol: IL3RA
• Synonyms: IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra
• Gene ID: 3563
• mRNA Refseq: NM_002183.4
• Protein Refseq: NP_002174.1
• MIM: 308385
• UniProt ID: P26951

Reviews

07/24/2022

In special environment, good stability.

05/25/2022

Good crystallization property and good effect.

06/29/2021

Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.

Q&As

Can Il3ra be personalized?

The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.

Does Il3ra have clinical application prospects? What are the prospects?

Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.

What is the action mechanism of Il3ra?

Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.

How is the clinical trial of Il3ra progressing?

Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.

What is the specific effect of Il3ra on the immune system?

The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.

Does Il3ra have side effects?

Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.