Recombinant Full Length Human MCM3 Protein, C-Flag-tagged
Cat.No. : | MCM3-1593HFL |
Product Overview : | Recombinant Full Length Human MCM3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 90.8 kDa |
AA Sequence : | MAGTVVLDDVELREAQRDYLDFLDD EEDQGIYQSKVRELISDNQYRLIVN VNDLRRKNEKRANRLLNNAF EELVAFQRALKDFVASIDATYAKQY EEFYVGLEGSFGSKHVSPRTLTSCF LSCVVCVEGIVTKCSLVRPK VVRSVHYCPATKKTIERRYSDLTTL VAFPSSSVYPTKDEENNPLETEYGL SVYKDHQTITIQEMPEKAPA GQLPRSVDVILDDDLVDKAKPGDRV QVVGTYRCLPGKKGGYTSGTFRTVL IACNVKQMSKDAQPSFSAED IAKIKKFSKTRSKDIFDQLAKSLAP SIHGHDYVKKAILCLLLGGVERDLE NGSHIRGDINILLIGDPSVA KSQLLRYVLCTAPRAIPTTGRGSSG VGLTAAVTTDQETGERRLEAGAMVL ADRGVVCIDEFDKMSDMDRT AIHEVMEQGRVTIAKAGIHARLNAR CSVLAAANPVYGRYDQYKTPMENIG LQDSLLSRFDLLFIMLDQMD PEQDREISDHVLRMHRYRAPGEQDG DAMPLGSAVDILATDDPNFSQEDQQ DTQIYEKHDNLLHGTKKKKE KMVSAAFMKKYIHVAKIIKPVLTQE SATYIAEEYSRLRSQDSMSSDTART SPVTARTLETLIRLATAHAK ARMSKTVDLQDAEEAVELVQYAYFK KVLEKEKKRKKRSEDESETEDEEEK SQEDQEQKRKRRKTRQPDAK DGDSYDPYDFSDTEEEMPQVHTPKT ADSQETKESQKVELSESRLKAFKVA LLDVFREAHAQSIGMNRLTE SINRDSEEPFSSVEIQAALSKMQDD NQVMVSEGIIFLITRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
Protein Pathways : | Cell cycle, DNA replication |
Gene Name : | MCM3 minichromosome maintenance complex component 3 [ Homo sapiens (human) ] |
Official Symbol : | MCM3 |
Synonyms : | HCC5; P1.h; RLFB; P1-MCM3 |
Gene ID : | 4172 |
mRNA Refseq : | NM_002388.6 |
Protein Refseq : | NP_002379.4 |
MIM : | 602693 |
UniProt ID : | P25205 |
Products Types
◆ Recombinant Protein | ||
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Mcm3-3996M | Recombinant Mouse Mcm3 Protein, Myc/DDK-tagged | +Inquiry |
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MCM3-11847Z | Recombinant Zebrafish MCM3 | +Inquiry |
◆ Lysates | ||
MCM3-4419HCL | Recombinant Human MCM3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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