Recombinant Full Length Human MITF Protein, GST-tagged

• Cat.No.: MITF-6272HF
• Product Overview: Human MITF full-length ORF ( NP_937802.1, 1 a.a. - 520 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 84.6 kDa
• Protein Length: 520 amino acids
• AA Sequence: MQSESGIVPDFEVGEEFHEEPKTYY ELKSQPLKSSSSAEHPGASKPPISS SSMTSRILLRQQLMREQMQEQERRE QQQKLQAAQFMQQRVPVSQTPAINV SVPTTLPSATQVPMEVLKVQTHLEN PTKYHIQQAQRQQVKQYLSTTLANK HANQVLSLPCPNQPGDHVMPPVPGS SAPNSPMAMLTLNSNCEKEGFYKFE EQNRAESECPGMNTHSRASCMQMDD VIDDIISLESSYNEEILGLMDPALQ MANTLPVSGNLIDLYGNQGLPPPGL TISNSCPANLPNIKRELTESEARAL AKERQKKDNHNLIERRRRFNINDRI KELGTLIPKSNDPDMRWNKGTILKA SVDYIRKLQREQQRAKELENRQKKL EHANRHLLLRIQELEMQARAHGLSL IPSTGLCSPDLVNRIIKQEPVLENC SQDLLQHHADLTCTTTLDLTDGTIT FNNNLGTGTEANQAYSVPTKMGSKL EDILMDDTLSPVGVTDPLLSSVSPG ASKTSSRRSSMSMEETEHTC
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MITF microphthalmia-associated transcription factor [ Homo sapiens ]
• Official Symbol: MITF
• Synonyms: MITF; microphthalmia-associated transcription factor; Waardenburg syndrome, type 2A , WS2, WS2A; bHLHe32; homolog of mouse microphthalmia; MI; class E basic helix-loop-helix protein 32; WS2; WS2A
• Gene ID: 4286
• mRNA Refseq: NM_000248
• Protein Refseq: NP_000239
• MIM: 156845
• UniProt ID: O75030