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Recombinant Full Length Human MMP3 Protein, C-Flag-tagged

Cat.No. : MMP3-890HFL
Product Overview : Recombinant Full Length Human MMP3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 52.2 kDa
AA Sequence : MKSLPILLLLCVAVCSAYPLDGAAR GEDTSMNLVQKYLENYYDLEKDVKQ FVRRKDSGPVVKKIREMQKF LGLEVTGKLDSDTLEVMRKPRCGVP DVGHFRTFPGIPKWRKTHLTYRIVN YTPDLPKDAVDSAVEKALKV WEEVTPLTFSRLYEGEADIMISFAV REHGDFYPFDGPGNVLAHAYAPGPG INGDAHFDDDEQWTKDTTGT NLFLVAAHEIGHSLGLFHSANTEAL MYPLYHSLTDLTRFRLSQDDINGIQ SLYGPPPDSPETPLVPTEPV PPEPGTPANCDPALSFDAVSTLRGE ILIFKDRHFWRKSLRKLEPELHLIS SFWPSLPSGVDAAYEVTSKD LVFIFKGNQFWAIRGNEVRAGYPRG IHTLGFPPTVRKIDAAISDKEKNKT YFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFG FFYFFTGSSQLEFDPNAKKVTHTLK SNSWLNCTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protease
Gene Name : MMP3 matrix metallopeptidase 3 [ Homo sapiens (human) ]
Official Symbol : MMP3
Synonyms : SL-1; STMY; STR1; CHDS6; MMP-3; STMY1
Gene ID : 4314
mRNA Refseq : NM_002422.5
Protein Refseq : NP_002413.1
MIM : 185250
UniProt ID : P08254

Not For Human Consumption!

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12/05/2020

    Critical expertise in protein engineering, a trusted partner in research.

    03/21/2020

      Swift and reliable protein sequencing, a key asset for our work.

      01/22/2020

        High-quality protein crystallography services, consistently delivers exceptional outcomes.

        Q&As (7)

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        How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling? 10/21/2022

        MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

        What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation? 07/04/2022

        MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

        How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions? 10/19/2021

        Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

        How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation? 07/01/2021

        MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

        What role does MMP3 play in the progression of arthritis and joint degeneration? 09/03/2019

        MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

        What are the mechanisms by which MMP3 modulates inflammatory responses? 06/13/2019

        MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

        How does MMP3 contribute to wound healing and tissue repair processes? 12/31/2018

        MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.

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