Recombinant Full Length Human NPLOC4 Protein, Flag-tagged

• Cat.No.: NPLOC4-1349HFL
• Product Overview: Recombinant Full Length protein of human nuclear protein localization 4 homolog (S. cerevisiae) (NPLOC4) with a Flag tag was expressed in HEK293T.

Specification

• Description: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I.
• Source: HEK293T
• Species: Human
• Tag: Flag
• Molecular Mass: 67.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Notes: For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol

Gene Information

• Gene Name: NPLOC4 NPL4 homolog, ubiquitin recognition factor [ Homo sapiens (human) ]
• Official Symbol: NPLOC4
• Synonyms: NPLOC4; NPL4 homolog, ubiquitin recognition factor; NPL4; nuclear protein localization protein 4 homolog; NPLOC4 ubiquitin recognition factor; nuclear protein localization 4 homolog
• Gene ID: 55666
• mRNA Refseq: NM_017921
• Protein Refseq: NP_060391
• MIM: 606590
• UniProt ID: Q8TAT6