Recombinant Full Length Human NRDC Protein, C-Flag-tagged

• Cat.No.: NRDC-1285HFL
• Product Overview: Recombinant Full Length Human NRDC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 139.2 kDa
• AA Sequence: MLRRVTVAAVCATRRKLCEAGRDVA ALWGIETRGRCEDSAAARPFPILAM PGRNKAKSTCSCPDLQPNGQ DLGENSRVARLGADESEEEGRRGSL SNAGDPEIVKSPSDPKQYRYIKLQN GLQALLISDLSNMEGKTGNT TDDEEEEEVEEEEEDDDEDSGAEIE DDDEEGFDDEDEFDDEHDDDLDTED NELEELEERAEARKKTTEKQ QLQSLFLLWSKLTDRLWFKSTYSKM SSTLLVETRNLYGVVGAESRSAPVQ HLAGWQAEEQQGETDTVLSA AALCVGVGSFADPDDLPGLAHFLEH MVFMGSLKYPDENGFDAFLKKHGGS DNASTDCERTVFQFDVQRKY FKEALDRWAQFFIHPLMIRDAIDRE VEAVDSEYQLARPSDANRKEMLFGS LARPGHPMGKFFWGNAETLK HEPRKNNIDTHARLREFWMRYYSSH YMTLVVQSKETLDTLEKWVTEIFSQ IPNNGLPRPNFGHLTDPFDT PAFNKLYRVVPIRKIHALTITWALP PQQQHYRVKPLHYISWLVGHEGKGS ILSFLRKKCWALALFGGNGE TGFEQNSTYSVFSISITLTDEGYEH FYEVAYTVFLYLKMLQKLGPEKRIF EEIRKIEDNEFHYQEQTDPV EYVENMCENMQLYPLQDILTGDQLL FEYKPEVIGEALNQLVPQKANLVLL SGANEGKCDLKEKWFGTQYS IEDIENSWAELWNSNFELNPDLHLP AENKYIATDFTLKAFDCPETEYPVK IVNTPQGCLWYKKDNKFKIP KAYIRFHLISPLIQKSAANVVLFDI FVNILTHNLAEPAYEADVAQLEYKL AAGEHGLIIRVKGFNHKLPL LFQLIIDYLAEFNSTPAVFTMITEQ LKKTYFNILIKPETLAKDVRLLILE YARWSMIDKYQALMDGLSLE SLLSFVKEFKSQLFVEGLVQGNVTS TESMDFLKYVVDKLNFKPLEQEMPV QFQVVELPSGHHLCKVKALN KGDANSEVTVYYQSGTRSLREYTLM ELLVMHMEEPCFDFLRTKQTLGYHV YPTCRNTSGILGFSVTVGTQ ATKYNSEVVDKKIEEFLSSFEEKIE NLTEEAFNTQVTALIKLKECEDTHL GEEVDRNWNEVVTQQYLFDR LAHEIEALKSFSKSDLVNWFKAHRG PGSKMLSVHVVGYGKYELEEDGSPS SEDSNSSCEVMQLTYLPTSP
  LLADCIIPITDIRAFTTTLNLLPYH KIVKTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease

Gene Information

• Gene Name: NRDC nardilysin convertase [ Homo sapiens (human) ]
• Official Symbol: NRDC
• Synonyms: NRD1; hNRD1; hNRD2
• Gene ID: 4898
• mRNA Refseq: NM_002525.3
• Protein Refseq: NP_002516.2
• MIM: 602651
• UniProt ID: O43847