Recombinant Full Length Human OPRM1 Protein, C-Flag-tagged

• Cat.No.: OPRM1-64HFL
• Product Overview: Recombinant Full Length Human OPRM1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 44.6 kDa
• AA Sequence: MDSSAAPTNASNCTDALAYSSCSPA PSPGSWVNLSHLDGNLSDPCGPNRT DLGGRDSLCPPTGSPSMITA ITIMALYSIVCVVGLFGNFLVMYVI VRYTKMKTATNIYIFNLALADALAT STLPFQSVNYLMGTWPFGTI LCKIVISIDYYNMFTSIFTLCTMSV DRYIAVCHPVKALDFRTPRNAKIIN VCNWILSSAIGLPVMFMATT KYRQGSIDCTLTFSHPTWYWENLLK ICVFIFAFIMPVLIITVCYGLMILR LKSVRMLSGSKEKDRNLRRI TRMVLVVVAVFIVCWTPIHIYVIIK ALVTIPETTFQTVSWHFCIALGYTN SCLNPVLYAFLDENFKRCFR
  EFCIPTSSNIEQQNSTRIRQNTRDH PSTANTVDRTNHQLENLEAETAPLP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction

Gene Information

• Gene Name: OPRM1 opioid receptor mu 1 [ Homo sapiens (human) ]
• Official Symbol: OPRM1
• Synonyms: MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
• Gene ID: 4988
• mRNA Refseq: NM_000914.5
• Protein Refseq: NP_000905.3
• MIM: 600018
• UniProt ID: P35372