Recombinant Full Length Human PKLR Protein, C-Flag-tagged
Cat.No. : | PKLR-1092HFL |
Product Overview : | Recombinant Full Length Human PKLR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 61.6 kDa |
AA Sequence : | MSIQENISSLQLRSWVSKSQRDLAK SILIGAPGGPAGYLRRASVAQLTQE LGTAFFQQQQLPAAMADTFL EHLCLLDIDSEPVAARSTSIIATIG PASRSVERLKEMIKAGMNIARLNFS HGSHEYHAESIANVREAVES FAGSPLSYRPVAIALDTKGPEIRTG ILQGGPESEVELVKGSQVLVTVDPA FRTRGNANTVWVDYPNIVRV VPVGGRIYIDDGLISLVVQKIGPEG LVTQVENGGVLGSRKGVNLPGAQVD LPGLSEQDVRDLRFGVEHGV DIVFASFVRKASDVAAVRAALGPEG HGIKIISKIENHEGVKRFDEILEVS DGIMVARGDLGIEIPAEKVF LAQKMMIGRCNLAGKPVVCATQMLE SMITKPRPTRAETSDVANAVLDGAD CIMLSGETAKGNFPVEAVKM QHAIAREAEAAVYHRQLFEELRRAA PLSRDPTEVTAIGAVEAAFKCCAAA IIVLTTTGRSAQLLSRYRPR AAVIAVTRSAQAARQVHLCRGVFPL LYREPPEAIWADDVDRRVQFGIESG KLRGFLRVGDLVIVVTGWRP GSGYTNIMRVLSISTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus |
Gene Name : | PKLR pyruvate kinase L/R [ Homo sapiens (human) ] |
Official Symbol : | PKLR |
Synonyms : | PK1; PKL; RPK; PKRL |
Gene ID : | 5313 |
mRNA Refseq : | NM_000298.6 |
Protein Refseq : | NP_000289.1 |
MIM : | 609712 |
UniProt ID : | P30613 |
Products Types
◆ Recombinant Protein | ||
PKLR-1486R | Recombinant Rat PKLR Protein (1-574 aa), His-tagged | +Inquiry |
PKLR-1485H | Recombinant Human PKLR Protein (1-574 aa), His-tagged | +Inquiry |
PKLR-1687H | Recombinant Human PKLR Protein, His (Fc)-Avi-tagged | +Inquiry |
Pklr-4887M | Recombinant Mouse Pklr Protein, Myc/DDK-tagged | +Inquiry |
PKLR-721R | Recombinant Rat PKLR Protein (1-574 aa), His-tagged | +Inquiry |
◆ Native Protein | ||
PKLR-244R | Active Native Rabbit Pyruvate Kinase | +Inquiry |
◆ Lysates | ||
PKLR-3154HCL | Recombinant Human PKLR 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket