Recombinant Full Length Human PON2 Protein, C-Flag-tagged

• Cat.No.: PON2-1153HFL
• Product Overview: Recombinant Full Length Human PON2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 39.2 kDa
• AA Sequence: MGRLVAVGLLGIALALLGERLLALR NRLKASREVESVDLPHCHLIKGIEA GSEDIDILPNGLAFFSVGLK FPGLHSFAPDKPGGILMMDLKEEKP RARELRISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTV EIFKFEEAENSLLHLKTVKHELLPS VNDITAVGPAHFYATNDHYFSDPFL KYLETYLNLHWANVVYYSPN EVKVVAEGFDSANGINISPDDKYIY VADILAHEIHVLEKHTNMNLTQLKV LELDTLVDNLSIDPSSGDIW VGCHPNGQKLFVYDPNNPPSSEVLR IQNILSEKPTVTTVYANNGSVLQGS SVASVYDGKLLIGTLYHRAL
  YCELTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways

Gene Information

• Gene Name: PON2 paraoxonase 2 [ Homo sapiens (human) ]
• Official Symbol: PON2
• Synonyms: A-esterase 2; aromatic esterase 2; paraoxonase 2; paraoxonase nirs; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2
• Gene ID: 5445
• mRNA Refseq: NM_000305.3
• Protein Refseq: NP_000296.2
• MIM: 602447
• UniProt ID: Q15165