Recombinant Full Length Human PRDM12 Protein, C-Flag-tagged

• Cat.No.: PRDM12-802HFL
• Product Overview: Recombinant Full Length Human PRDM12 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.2 kDa
• AA Sequence: MMGSVLPAEALVLKTGLKAPGLALA EVITSDILHSFLYGRWRNVLGEQLF EDKSHHASPKTAFTAEVLAQ SFSGEVQKLSSLVLPAEVIIAQSSI PGEGLGIFSKTWIKAGTEMGPFTGR VIAPEHVDICKNNNLMWEVF NEDGTVRYFIDASQEDHRSWMTYIK CARNEQEQNLEVVQIGTSIFYKAIE MIPPDQELLVWYGNSHNTFL GIPGVPGLEEDQKKNKHEDFHPADS AAGPAGRMRCVICHRGFNSRSNLRS HMRIHTLDKPFVCRFCNRRF SQSSTLRNHVRLHTGERPYKCQVCQ SAYSQLAGLRAHQKSARHRPPSTAL QAHSPALPAPHAHAPALAAA
  AAAAAAAAAHHLPAMVLTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: PRDM12 PR/SET domain 12 [ Homo sapiens (human) ]
• Official Symbol: PRDM12
• Synonyms: PFM9; HSAN8
• Gene ID: 59335
• mRNA Refseq: NM_021619.3
• Protein Refseq: NP_067632.2
• MIM: 616458
• UniProt ID: Q9H4Q4