Recombinant Full Length Human RGS4 Protein, C-Flag-tagged

• Cat.No.: RGS4-1464HFL
• Product Overview: Recombinant Full Length Human RGS4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 23.1 kDa
• AA Sequence: MCKGLAGLPASCLRSAKDMKHRLGF LLQKSDSCEHNSSHNKKDKVVICQR VSQEEVKKWAESLENLISHE CGLAAFKAFLKSEYSEENIDFWISC EEYKKIKSPSKLSPKAKKIYNEFIS VQATKEVNLDSCTREETSRN MLEPTITCFDEAQKKIFNLMEKDSY RRFLKSRFYLDLVNPSSCGAEKQKG AKSSADCASLVPQCATRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: RGS4 regulator of G protein signaling 4 [ Homo sapiens (human) ]
• Official Symbol: RGS4
• Synonyms: RGP4; SCZD9
• Gene ID: 5999
• mRNA Refseq: NM_005613.6
• Protein Refseq: NP_005604.1
• MIM: 602516
• UniProt ID: P49798