Recombinant Full Length Human ROR2 Protein, C-Flag-tagged

• Cat.No.: ROR2-1130HFL
• Product Overview: Recombinant Full Length Human ROR2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 101.3 kDa
• AA Sequence: MARGSALPRRPLLCIPAVWAAAALL LSVSRTSGEVEVLDPNDPLGPLDGQ DGPIPTLKGYFLNFLEPVNN ITIVQGQTAILHCKVAGNPPPNVRW LKNDAPVVQEPRRIIIRKTEYGSRL RIQDLDTTDTGYYQCVATNG MKTITATGVLFVRLGPTHSPNHNFQ DDYHEDGFCQPYRGIACARFIGNRT IYVDSLQMQGEIENRITAAF TMIGTSTHLSDQCSQFAIPSFCHFV FPLCDARSRAPKPRELCRDECEVLE SDLCRQEYTIARSNPLILMR LQLPKCEALPMPESPDAANCMRIGI PAERLGRYHQCYNGSGMDYRGTAST TKSGHQCQPWALQHPHSHHL SSTDFPELGGGHAYCRNPGGQMEGP WCFTQNKNVRMELCDVPSCSPRDSS KMGILYILVPSIAIPLVIAC LFFLVCMCRNKQKASASTPQRRQLM ASPSQDMEMPLINQHKQAKLKEISL SAVRFMEELGEDRFGKVYKG HLFGPAPGEQTQAVAIKTLKDKAEG PLREEFRHEAMLRARLQHPNVVCLL GVVTKDQPLSMIFSYCSHGD LHEFLVMRSPHSDVGSTDDDRTVKS ALEPPDFVHLVAQIAAGMEYLSSHH VVHKDLATRNVLVYDKLNVK ISDLGLFREVYAADYYKLLGNSLLP IRWMAPEAIMYGKFSIDSDIWSYGV VLWEVFSYGLQPYCGYSNQD VVEMIRNRQVLPCPDDCPAWVYALM IECWNEFPSRRPRFKDIHSRLRAWG NLSNYNSSAQTSGASNTTQT SSLSTSPVSNVSNARYVGPKQKAPP FPQPQFIPMKGQIRPMVPPPQLYIP VNGYQPVPAYGAYLPNFYPV QIPMQMAPQQVPPQMVPKPSSHHSG SGSTSTGYVTTAPSNTSMADRAALL SEGADDTQNAPEDGAQSTVQ
  EAEEEEEGSVPETELLGDCDTLQVD EAQVQLEATRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane

Gene Information

• Gene Name: ROR2 receptor tyrosine kinase like orphan receptor 2 [ Homo sapiens (human) ]
• Official Symbol: ROR2
• Synonyms: BDB; BDB1; NTRKR2
• Gene ID: 4920
• mRNA Refseq: NM_004560.4
• Protein Refseq: NP_004551.2
• MIM: 602337
• UniProt ID: Q01974