Recombinant Full Length Human SGCB Protein, C-Flag-tagged

• Cat.No.: SGCB-173HFL
• Product Overview: Recombinant Full Length Human SGCB Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 34.6 kDa
• AA Sequence: MAAAAAAAAEQQSSNGPVKKSMREK AVERRSVNKEHNSNFKAGYIPIDED RLHKTGLRGRKGNLAICVII LLFILAVINLIITLVIWAVIRIGPN GCDSMEFHESGLLRFKQVSDMGVIH PLYKSTVGGRRNENLVITGN NQPIVFQQGTTKLSVENNKTSITSD IGMQFFDPRTQNILFSTDYETHEFH LPSGVKSLNVQKASTERITS NATSDLNIKVDGRAIVRGNEGVFIM GKTIEFHMGGNMELKAENSIILNGS VMVSTTRLPSSSSGDQLGSG
  DWVRYKLCMCADGTLFKVQVTSQNM GCQISDNPCGNTHTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Viral myocarditis

Gene Information

• Gene Name: SGCB sarcoglycan beta [ Homo sapiens (human) ]
• Official Symbol: SGCB
• Synonyms: A3b; SGC; LGMD2E; LGMDR4
• Gene ID: 6443
• mRNA Refseq: NM_000232.5
• Protein Refseq: NP_000223.1
• MIM: 600900
• UniProt ID: Q16585