Recombinant Full Length Human SIRPB1 Protein, C-Flag-tagged

• Cat.No.: SIRPB1-1499HFL
• Product Overview: Recombinant Full Length Human SIRPB1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.8 kDa
• AA Sequence: MPVPASWPHLPSPFLLMTLLLGRLT GVAGEDELQVIQPEKSVSVAAGESA TLCCAMTSLIPVGPIMWFRG AGAGRELIYNQKEGHFPRVTTVSEL TKRNNLDFSISISNITPADAGTYYC VKFRKGSPDDVEFKSGAGTE LSVRAKPSAPVVSGPAVRATPEHTV SFTCESHGFSPRDITLKWFKNGNEL SDFQTNVDPAGDSVSYSIHS TARVVLTRGDVHSQVICEMAHITLQ GDPLRGTANLSEAIRVPPTLEVTQQ PMRAENQANVTCQVSNFYPR GLQLTWLENGNVSRTETASTLIENK DGTYNWMSWLLVNTCAHRDDVVLTC QVEHDGQQAVSKSYALEISA
  HQKEHGSDITHEPALAPTAPLLVAL LLGPKLLLVVGVSAIYICWKQKATR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: SIRPB1 signal regulatory protein beta 1 [ Homo sapiens (human) ]
• Official Symbol: SIRPB1
• Synonyms: CD172b; SIRP-BETA-1
• Gene ID: 10326
• mRNA Refseq: NM_006065.5
• Protein Refseq: NP_006056.2
• MIM: 603889
• UniProt ID: O00241