| Description : |
This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid, 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
| Molecular Mass : |
56 kDa |
| Protein Length : |
287 amino acids |
| AA Sequence : |
MELKKSPDGGWGWVIVFVSFLTQFL CYGSPLAVGVLYIEWLDAFGEGKGK TAWVGSLASGVGLLASPVCSLCVSS FGARPVTIFSGFMVAGGLMLSSFAP NIYFLFFSYGIVVGLGCGLLYTATV TITCQYFDDRRGLALGLISTGSSVG LFIYAALQRMLVEFYGLDGCLLIVG ALALNILACGSLMRPLQSSDCPLPK KIAPEDLPDKYSIYNEKGKNLEENI NILDKSYSSEEKCRITLANGDWKQD SLLHKNPTVTHTKEPETYKKKVAEQ TYFCKQLAKRKWQLYKNYCGETVAL FKNKVFSALFIAILLFDIGGFPPSL LMEDVARSSNVKEEEFIMPLISIIG IMTAVGKLLLGILADFKWINTLYLY VATLIIMGLALCAIPFAKSYVTLAL LSGILGFLTGNWSIFPYVTTKTVGI EKLAHAYGILMFFAGLGNSLGPPIV GWFYDWTQTYDIAFYFSGFCVLLGG FILLLAALPSWDTCNKQLPKPAPTT FLYKVASNV |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
