Recombinant Full Length Human SLC18A2 Protein, C-Flag-tagged

• Cat.No.: SLC18A2-1559HFL
• Product Overview: Recombinant Full Length Human SLC18A2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 55.5 kDa
• AA Sequence: MALSELALVRWLQESRRSRKLILFI VFLALLLDNMLLTVVVPIIPSYLYS IKHEKNATEIQTARPVHTAS ISDSFQSIFSYYDNSTMVTGNATRD LTLHQTATQHMVTNASAVPSDCPSE DKDLLNENVQVGLLFASKAT VQLITNPFIGLLTNRIGYPIPIFAG FCIMFVSTIMFAFSSSYAFLLIARS LQGIGSSCSSVAGMGMLASV YTDDEERGNVMGIALGGLAMGVLVG PPFGSVLYEFVGKTAPFLVLAALVL LDGAIQLFVLQPSRVQPESQ KGTPLTTLLKDPYILIAAGSICFAN MGIAMLEPALPIWMMETMCSRKWQL GVAFLPASISYLIGTNIFGI LAHKMGRWLCALLGMIIVGVSILCI PFAKNIYGLIAPNFGVGFAIGMVDS SMMPIMGYLVDLRHVSVYGS VYAIADVAFCMGYAIGPSAGGAIAK AIGFPWLMTIIGIIDILFAPLCFFL RSPPAKEEKMAILMDHNCPI
  KTKMYTQNNIQSYPIGEDEESESDS GPTRTRRLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane
• Protein Pathways: Parkinson's disease

Gene Information

• Gene Name: SLC18A2 solute carrier family 18 member A2 [ Homo sapiens (human) ]
• Official Symbol: SLC18A2
• Synonyms: SVAT; SVMT; VAT2; VMAT2; PKDYS2
• Gene ID: 6571
• mRNA Refseq: NM_003054.6
• Protein Refseq: NP_003045.2
• MIM: 193001
• UniProt ID: Q05940