Recombinant Full Length Human SSB Protein, C-Flag-tagged

• Cat.No.: SSB-864HFL
• Product Overview: Recombinant Full Length Human SSB Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 46.7 kDa
• AA Sequence: MAENGDNEKMAALEAKICHQIEYYF GDFNLPRDKFLKEQIKLDEGWVPLE IMIKFNRLNRLTTDFNVIVE ALSKSKAELMEISEDKTKIRRSPSK PLPEVTDEYKNDVKNRSVYIKGFPT DATLDDIKEWLEDKGQVLNI QMRRTLHKAFKGSIFVVFDSIESAK KFVETPGQKYKETDLLILFKDDYFA KKNEERKQNKVEAKLRAKQE QEAKQKLEEDAEMKSLEEKIGCLLK FSGDLDDQTCREDLHILFSNHGEIK WIDFVRGAKEGIILFKEKAK EALGKAKDANNGNLQLRNKEVTWEV LEGEVEKEALKKIIEDQQESLNKWK SKGRRFKGKGKGNKAAQPGS
  GKGKVQFQGKKTKFASDDEHDEHDE NGATGPVKRAREETDKEEPASKQQK TENGAGDQTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Systemic lupus erythematosus

Gene Information

• Gene Name: SSB small RNA binding exonuclease protection factor La [ Homo sapiens (human) ]
• Official Symbol: SSB
• Synonyms: La; LARP3; La/SSB
• Gene ID: 6741
• mRNA Refseq: NM_003142.5
• Protein Refseq: NP_003133.1
• MIM: 109090
• UniProt ID: P05455