Recombinant Full Length Human STAM Protein, C-Flag-tagged

• Cat.No.: STAM-1315HFL
• Product Overview: Recombinant Full Length Human STAM Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 59 kDa
• AA Sequence: MPLFATNPFDQDVEKATSEMNTAED WGLILDICDKVGQSRTGPKDCLRSI MRRVNHKDPHVAMQALTLLG ACVSNCGKIFHLEVCSRDFASEVSN VLNKGHPKVCEKLKALMVEWTDEFK NDPQLSLISAMIKNLKEQGV TFPAIGSQAAEQAKASPALVAKDPG TVANKKEEEDLAKAIELSLKEQRQQ STTLSTLYPSTSSLLTNHQH EGRKVRAIYDFEAAEDNELTFKAGE IITVLDDSDPNWWKGETHQGIGLFP SNFVTADLTAEPEMIKTEKK TVQFSDDVQVETIEPEPEPAFIDED KMDQLLQMLQSTDPSDDQPDLPELL HLEAMCHQMGPLIDEKLEDI DRKHSELSELNVKVMEALSLYTKLM NEDPMYSMYAKLQNQPYYMQSSGVS GSQVYAGPPPSGAYLVAGNA QMSHLQSYSLPPEQLSSLSQAVVPP SANPALPSQQTQAAYPNTMVSSVQG NTYPSQAPVYSPPPAATAAA
  ATADVTLYQNAGPNMPQVPNYNLTS STLPQPGGSQQPPQPQQPYSQKALL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Endocytosis, Jak-STAT signaling pathway

Gene Information

• Gene Name: STAM signal transducing adaptor molecule [ Homo sapiens (human) ]
• Official Symbol: STAM
• Synonyms: STAM1; STAM-1
• Gene ID: 8027
• mRNA Refseq: NM_003473.4
• Protein Refseq: NP_003464.1
• MIM: 601899
• UniProt ID: Q92783