Recombinant Full Length Human TGM1 Protein, C-Flag-tagged

• Cat.No.: TGM1-1420HFL
• Product Overview: Recombinant Full Length Human TGM1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 89.6 kDa
• AA Sequence: MMDGPRSDVGRWGGNPLQPPTTPSP EPEPEPDGRSRRGGGRSFWARCCGC CSCRNAADDDWGPEPSDSRG RGSSSGTRRPGSRGSDSRRPVSRGS GVNAAGDGTIREGMLVVNGVDLLSS RSDQNRREHHTDEYEYDELI VRRGQPFHMLLLLSRTYESSDRITL ELLIGNNPEVGKGTHVIIPVGKGGS GGWKAQVVKASGQNLNLRVH TSPNAIIGKFQFTVRTQSDAGEFQL PFDPRNEIYILFNPWCPEDIVYVDH EDWRQEYVLNESGRIYYGTE AQIGERTWNYGQFDHGVLDACLYIL DRRGMPYGGRGDPVNVSRVISAMVN SLDDNGVLIGNWSGDYSRGT NPSAWVGSVEILLSYLRTGYSVPYG QCWVFAGVTTTVLRCLGLATRTVTN FNSAHDTDTSLTMDIYFDEN MKPLEHLNHDSVWNFHVWNDCWMKR PDLPSGFDGWQVVDATPQETSSGIF CCGPCSVESIKNGLVYMKYD TPFIFAEVNSDKVYWQRQDDGSFKI VYVEEKAIGTLIVTKAISSNMREDI TYLYKHPEGSDAERKAVETA AAHGSKPNVYANRGSAEDVAMQVEA QDAVMGQDLMVSVMLINHSSSRRTV KLHLYLSVTFYTGVSGTIFK ETKKEVELAPGASDRVTMPVAYKEY RPHLVDQGAMLLNVSGHVKESGQVL AKQHTFRLRTPDLSLTLLGA AVVGQECEVQIVFKNPLPVTLTNVV FRLEGSGLQRPKILNVGDIGGNETV TLRQSFVPVRPGPRQLIASL
  DSPQLSQVHGVIQVDVAPAPGDGGF FSDAGGDSHLGETIPMASRGGATRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: TGM1 transglutaminase 1 [ Homo sapiens (human) ]
• Official Symbol: TGM1
• Synonyms: LI; KTG; LI1; TGK; ICR2; ARCI1; TGASE
• Gene ID: 7051
• mRNA Refseq: NM_000359.3
• Protein Refseq: NP_000350.1
• MIM: 190195
• UniProt ID: P22735