Recombinant Full Length Human TNFRSF4 Protein, C-Flag-tagged

• Cat.No.: TNFRSF4-982HFL
• Product Overview: Recombinant Full Length Human TNFRSF4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 26.6 kDa
• AA Sequence: MCVGARRLGRGPCAALLLLGLGLST VTGLHCVGDTYPSNDRCCHECRPGN GMVSRCSRSQNTVCRPCGPG FYNDVVSSKPCKPCTWCNLRSGSER KQLCTATQDTVCRCRAGTQPLDSYK PGVDCAPCPPGHFSPGDNQA CKPWTNCTLAGKHTLQPASNSSDAI CEDRDPPATQPQETQGPPARPITVQ PTEAWPRTSQGPSTRPVEVP GGRAVAAILGLGLVLGLLGPLAILL ALYLLRRDQRLPPDAHKPPGGGSFR TPIQEEQADAHSTLAKITRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction

Gene Information

• Gene Name: TNFRSF4 TNF receptor superfamily member 4 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF4
• Synonyms: OX40; ACT35; CD134; IMD16; TXGP1L
• Gene ID: 7293
• mRNA Refseq: NM_003327.4
• Protein Refseq: NP_003318.1
• MIM: 600315
• UniProt ID: P43489