Recombinant Full Length Human TOMM22 Protein, GST-tagged

• Cat.No.: TOMM22-6861HF
• Product Overview: Human TOMM22 full-length ORF ( AAH09363, 1 a.a. - 142 a.a.) recombinant protein with GST-tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 41.36 kDa
• Protein Length: 142 amino acids
• AA Sequence: MAAAVAAAGAGEPQSPDELLPKGDA EKPEEELEEDDDEELDETLSERLWG LTEMFPERVRSAAGATFDLSLFVAQ KMYRFSRAALWIGTTSFMILVLPVV FETEKLQMEQQQQLQQRQILLGPNT GLSGGMPGALPSLPGKI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: TOMM22 translocase of outer mitochondrial membrane 22 [ Homo sapiens (human) ]
• Official Symbol: TOMM22
• Synonyms: TOMM22; translocase of outer mitochondrial membrane 22; 1C9-2; TOM22; MST065; MSTP065; mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog
• Gene ID: 56993
• mRNA Refseq: NM_020243
• Protein Refseq: NP_064628
• MIM: 607046
• UniProt ID: Q9NS69

Reviews

06/27/2023

The production process of their recombinant protein is strictly controlled, and the quality of the products is guaranteed.

08/30/2022

The high band intensity in Western blot improves the signal-to-noise ratio of the experiment.

12/24/2020

It has strong acid and alkali resistance, and is still active under complex conditions.

Q&As

What is the role of TOMM22 in apoptosis?

Studies have shown that TOMM22 may be involved in the process of apoptosis. However, its specific mechanism of action and function still need further research.

How is TOMM22 involved in mitochondrial protein transport?

TOMM22 forms a protein transport channel by interacting with TOMM40 on the inner mitochondrial membrane to transport the proteins required by the mitochondria from the outer mitochondrial membrane to the inner mitochondrial membrane.

How is the expression level of TOMM22 regulated?

The expression level of TOMM22 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the TOMM22 gene, thereby regulating its expression level in cells.

Is TOMM22 related to other proteins?

TOMM22 interacts with other proteins, such as Tom40 on the outer mitochondrial membrane and Tom40 on the inner mitochondrial membrane. These interactions help regulate the function of TOMM22 in cells.

What diseases are associated with mutations or abnormal expression of TOMM22?

Mutations or aberrant expression of TOMM22 may be associated with a variety of diseases, including neurological diseases, cardiovascular diseases, and cancer. Studies have shown that reduced expression levels or impaired function of TOMM22 may contribute to the occurrence and progression of these diseases.

How is TOMM22 activity regulated?

The activity of TOMM22 can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These modulating mechanisms can affect the function of TOMM22.