Recombinant Full Length Human WWTR1 Protein, C-Flag-tagged
Cat.No. : | WWTR1-240HFL |
Product Overview : | Recombinant Full Length Human WWTR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 43.9 kDa |
AA Sequence : | MNPASAPPPLPPPGQQVIHVTQDLD TDLEALFNSVMNPKPSSWRKKILPE SFFKEPDSGSHSRQSSTDSS GGHPGPRLAGGAQHVRSHSSPASLQ LGTGAGAAGSPAQQHAHLRQQSYDV TDELPLPPGWEMTFTATGQR YFLNHIEKITTWQDPRKAMNQPLNH MNLHPAVSSTPVPQRSMAVSQPNLV MNHQHQQQMAPSTLSQQNHP TQNPPAGLMSMPNALTTQQQQQQKL RLQRIQMERERIRMRQEELMRQEAA LCRQLPMEAETLAPVQAAVN PPTMTPDMRSITNNSSDPFLNGGPY HSREQSTDSGLGLGCYSVPTTPEDF LSNVDEMDTGENAGQTPMNI NPQQTRFPDFLDCLPGTNVDLGTLE SEDLIPLFNDVESALNKSEPFLTWL TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transcription Factors |
Gene Name : | WWTR1 WW domain containing transcription regulator 1 [ Homo sapiens (human) ] |
Official Symbol : | WWTR1 |
Synonyms : | TAZ |
Gene ID : | 25937 |
mRNA Refseq : | NM_015472.6 |
Protein Refseq : | NP_056287.1 |
MIM : | 607392 |
UniProt ID : | Q9GZV5 |
Products Types
◆ Recombinant Protein | ||
WWTR1-2363H | Recombinant Human WWTR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
WWTR1-10217M | Recombinant Mouse WWTR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
WWTR1-18598M | Recombinant Mouse WWTR1 Protein | +Inquiry |
WWTR1-5796H | Recombinant Human WWTR1 Protein (Met1-Leu400), N-His tagged | +Inquiry |
WWTR1-3635H | Recombinant Human WWTR1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
WWTR1-272HCL | Recombinant Human WWTR1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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