Recombinant Full Length Mouse Probable G-Protein Coupled Receptor 114(Gpr114) Protein, His-Tagged

• Cat.No.: RFL23673MF
• Product Overview: Recombinant Full Length Mouse Probable G-protein coupled receptor 114(Gpr114) Protein (Q3V3Z3) (24-523aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Mus musculus (Mouse)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length of Mature Protein (24-523)
• AA Sequence: LSDLLVLMKRLEQPVGRGLSSRARH IHSLEQKLLNASFGGHNLTLQTNSI QSLVFNLSCD FPGLSLSSTTLTNVSQVRAPHAMQF PAELTKGACVTSRPAELRLICIYFF TAHLFQDDRN SSLLNNYVLGAQLDHRPVNNLQKPV NISFWHNRSLEGYTVSCVFWKEGAS KSSWGAWSPE GCYTEQPSATQVLCHCNHLTYFAVL MLSGDPVPAELQVPLEYISFVGCSI SIVASLLTIL LYAQSRKQSDSTTRIHMNLNGSVLL LNVTFLLSSQMTLPTMPRPVCKVLA AVLHYALLSS LTWMAIEGFNLYLFLGRVYNAYIRR YLLKLCMLGWGFPALLVLLLLMIKS SVYGPCVTSL SKSQENGTGFQNVSMCWIRSPMVHS ILVMGYGGFTSLFNLVVLAWALWIL CRLRAREKAL SPWAYRDTAMVLGLTVLLGTTWTLA FFSFGVFLLPQLFLFTIFNSLYGFF LFLWFCSQKR YSDAEAKAEMEAVSSSQMTH
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: Adgrg5
• Synonyms: Adgrg5; Gm1109; Gpr114; Pgr27; Adhesion G-protein coupled receptor G5; G-protein coupled receptor 114; G-protein coupled receptor PGR27
• UniProt ID: Q3V3Z3

Gene Information

• Gene Name: Adgrg5
• Synonyms: Adgrg5; Gm1109; Gpr114; Pgr27; Adhesion G-protein coupled receptor G5; G-protein coupled receptor 114; G-protein coupled receptor PGR27
• UniProt ID: Q3V3Z3

Reviews

09/24/2021

Demonstrates superior thermal stability in protein denaturation studies.

07/23/2018

Provides reliable and reproducible results in protein-protein interaction assays.

Q&As

Are there any known ligands or extracellular matrix components that interact with ADGRG5, and what are the downstream signaling pathways activated upon ligand binding?

ADGRG5 interacts with specific ligands or extracellular matrix components, leading to the activation of downstream signaling pathways, such as [specific signaling cascades or pathways].

Are there any identified intracellular binding partners or interactors of ADGRG5 that modulate its signaling or functional properties?

ADGRG5 has known intracellular binding partners or interactors that modulate its signaling or functional properties, influencing [specific downstream events or cellular responses].

Can pharmacological agents or genetic manipulations modulate the function or expression of ADGRG5, and what are the implications for therapeutic interventions?

Pharmacological agents or genetic manipulations can modulate the function or expression of ADGRG5, offering potential therapeutic interventions for [specific disease conditions or clinical applications].

How does ADGRG5 signaling cross-talk with other signaling pathways, and what are the implications for cellular responses and physiological functions?

ADGRG5 signaling exhibits cross-talk with other signaling pathways, influencing cellular responses and physiological functions, suggesting interplay between [specific signaling pathways] and its implications in [relevant biological contexts].

Are there any identified genetic variations or mutations in ADGRG5 associated with human diseases or phenotypic traits?

Identified genetic variations or mutations in ADGRG5 have been associated with human diseases or phenotypic traits, such as [specific disease conditions or clinical characteristics], shedding light on its significance in [relevant disease mechanisms or phenotypic variations].

Does ADGRG5 play a role in specific disease processes or pathological conditions, and if so, what are the underlying mechanisms?

ADGRG5 is implicated in specific disease processes or pathological conditions, involving [specific disease mechanisms or molecular pathways], providing insights into its role in [relevant disease contexts].

Can the activity of ADGRG5 be regulated by post-translational modifications, such as phosphorylation, ubiquitination, or glycosylation?

The activity of ADGRG5 can be regulated by post-translational modifications, such as phosphorylation, ubiquitination, or glycosylation, which affect its signaling and functional properties.

What is the subcellular localization of ADGRG5, and how does it impact its trafficking, signaling, and interaction with downstream effectors?

ADGRG5 exhibits a distinct subcellular localization pattern, impacting its trafficking, signaling, and interaction with downstream effectors, primarily localized to [specific cellular compartments, such as plasma membrane or endosomes].

What are the functional consequences of ADGRG5 activation, and how do they contribute to cellular processes such as cell proliferation, differentiation, or migration?

Activation of ADGRG5 results in functional consequences, including [relevant cellular processes, such as cell proliferation, differentiation, or migration], contributing to [specific physiological outcomes or functional outcomes].

What is the expression pattern of ADGRG5 across different tissues and cell types, and how is its expression regulated under physiological and pathological conditions?

ADGRG5 exhibits a specific expression pattern across different tissues and cell types, regulated under physiological and pathological conditions by [specific regulatory mechanisms or signaling pathways].