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Recombinant H7N9(A/Anhui/1/2013) Neuraminidase Protein(Active)

Cat.No. : NA-492H
Product Overview : Recombinant H7N9(A/Anhui/1/2013) Neuraminidase (AGI60300.1) (His36-Leu465) was expressed , the cell lysates are collected, and bio-activity was tested.
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Description : Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell.

Influenza neuraminidase is composed of four identical subunits arranged in a square. It is normally attached to the virus surface through a long protein stalk. The active sites are in a deep depression on the upper surface. They bind to polysaccharide chains and clip off the sugars at the end. The surface of neuraminidase is decorated with several polysaccharide chains that are similar to the polysaccharide chains that decorate our own cell surface proteins.

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

Influenza antibody and influenza antibodies are very important research tools for influenza diagnosis, influenza vaccine development, and anti-influenza virus therapy development. Mon centigradelonal or polyclonal antibody can be raised with protein based antigen or peptide based antigen. Antibody raised with protein based antigen could have better specificity and/or binding affinity than antibody raised with peptide based antigen, but cost ass centigradeiated with the recombinant protein antigen is usually higher. Anti influenza virus hemagglutinin (HA) mon centigradelonal antibody or polyclonal antibody can be used for ELISA assay, western blotting detection, Immunohist centigradehemistry (IHC), flow cytometry, neutralization assay, hemagglutinin inhibition assay, and early diagnosis of influenza viral infection.
Source : HEK293
Species : H7N9
Form : Lyophilized from sterile PBS, 0.6%Triton-100, 6% trehalose 5.3% mannitol PH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its ability to cleave a fluorogenic substrate, 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid. The specific activity is > 100 U. One unit is defined as the amount of enzyme required to cleave 1 nmole of 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid per minute at pH 7.5 at 37 centigrade.
Molecular Mass : The influenza H7N9 virus Neuraminidase comprises 448 amino acids
Protein length : His36-Leu465
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Official Symbol : NA
Synonyms : Neuraminidase; NA
Official Symbol : NA
Synonyms : Neuraminidase; NA

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Are there NA protein-based therapies in clinical use? 05/01/2023

Yes, some RNA-based therapies target specific NA proteins for conditions like spinal muscular atrophy.

How do histones relate to epigenetic modifications and clinical outcomes? 08/07/2019

Changes in histone modifications can influence gene expression and contribute to various diseases.

How are NA proteins used in cancer research and treatment? 03/20/2019

NA proteins are studied to understand oncogenesis, and some drugs target NA protein interactions to treat cancer.

Can NA proteins be used for gene therapy? 07/18/2018

NA proteins can be involved in gene therapy strategies to manipulate gene expression for therapeutic purposes.

How are NA proteins involved in the regulation of cell cycle and cancer progression? 12/05/2016

NA proteins control the cell cycle, and dysregulation can contribute to uncontrolled cell growth seen in cancer.

Customer Reviews (3)

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11/26/2020

    I highly recommend the NA protein for a variety of experimental applications.

    09/08/2019

      I enthusiastically recommend the NA protein to fellow researchers who seek an unparalleled product accompanied by dedicated customer assistance.

      11/16/2018

        the NA protein stands out for its exceptional quality, coupled with the outstanding technical support delivered by the manufacturer.

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