Recombinant Hamster Il12b Protein, Met1-Ser327, C-His tagged

Cat.No. : Il12b-020H
Product Overview : Recombinant Hamster Il12b Protein (Met1-Ser327) with C-His tag was expressed in HEK293.
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Description : Interleukin 12 p40 subunit (IL-12p40) is a component of the bioactive cytokines IL-12 and IL-23. Existing in either a monomeric or homodimeric form, it is induced in excess of the other subunits of IL-12 and IL23. Most known for providing negative feedback by competing for the IL-12 receptor, it also functions as a chemoattractant for macrophages and is associated with several pathogenic inflammatory responses.
Source : HEK293
Species : Hamster
Tag : His
Protein length : Met1-Ser327
Form : Lyophilized
Molecular Mass : Predicted Molecular Mass: 36.5 kDa
SDS-PAGE: 45.9 kDa
Purity : > 95% as analyzed by SDS-PAGE
Applications : ELISA and Western Blot Analysis
Notes : For Research Use Only.
Storage : 2 years at -20 to -80 centigrade as supplied.
1 month at 4 centigrade after reconstitution with preservative.
1 year at -20 to -80 centigrade after reconstitution.
Storage Buffer : Lyophilized from 1×PBS with Trelahose
Shipping : Ambient
Reconstitution : Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% protein
Gene Name : Il12b interleukin 12B [ Cricetulus griseus (Chinese hamster) ]
Official Symbol : Il12b
Synonyms : Il12b; interleukin 12B; interleukin-12 subunit beta; Interleukin-12 subunit beta
Gene ID : 100764758
mRNA Refseq : XM_003502207
Protein Refseq : XP_003502255
UniProt ID : Q8CJE6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    Good for cytokine assays.


      Effective in Th2 cell differentiation.


        High yield in expression.

        Q&As (10)

        Ask a question
        Could you explain the use of ChIP-seq in studying IL12B transcriptional regulation? 05/12/2021

        ChIP-seq identifies regulatory elements controlling IL12B gene expression.

        Can you elaborate on the use of reporter assays to monitor IL12B promoter activity? 05/02/2021

        Reporter assays monitor IL12B promoter activity under varying conditions.

        What methods evaluate IL12B's response to different pathogenic stimuli in primary cells? 10/30/2020

        Primary cell stimulation assays gauge IL12B response to pathogens.

        How does siRNA knockdown of IL12B elucidate its role in immune cell activation? 05/25/2020

        siRNA knockdown uncovers IL12B's role in immune cell activation pathways.

        How does recombinant protein expression and purification aid in IL12B functional studies? 04/30/2020

        Recombinant protein expression enables functional IL12B studies in vitro.

        How does co-immunoprecipitation validate IL12B's association with signaling partners? 04/12/2018

        Co-IP validates IL12B's binding to specific signaling partners.

        What techniques are employed to analyze the impact of IL12B genetic variants on protein function? 12/03/2017

        Genetic variant analysis reveals impacts on IL12B protein function.

        How does flow cytometry reveal IL12B's expression dynamics in different immune cell subsets? 10/31/2017

        Flow cytometry profiles IL12B expression across diverse immune cell types.

        What experimental approaches determine IL12B's cytokine secretion kinetics upon stimulation? 09/29/2017

        Cytokine secretion assays measure IL12B's response kinetics to stimuli.

        What are the methods to assess IL12B's protein-protein interactions in a cellular context? 08/22/2017

        Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.

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