| Description : |
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. |
| Source : |
E. coli |
| Species : |
Hepatitis C Virus |
| Form : |
25 mM Tris-HCl pH 8.0, 1 mM EDTA, 1.5 M urea and 50% glycerol |
| Purity : |
> 95 % (SDS-PAGE, RP-HPLC) |
| Applications : |
ELISA; Western Blot |
| Storage : |
Store at -20 centigrade, avoid freeze/thaw cycles. |
| Official Symbol : |
Nucleocapsid |
| Synonyms : |
Nucleocapsid |
