Recombinant Human ABAT Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | ABAT-1795H |
| Product Overview : | ABAT MS Standard C13 and N15-labeled recombinant protein (NP_000654) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 56.5 kDa |
| AA Sequence : | MASMLLAQRL ACSFQHSYRL LVPGSRHISQ AAAKVDVEFD YDGPLMKTEV PGPRSRELMK QLNIIQNAEA VHFFCNYEES RGNYLVDVDG NRMLDLYSQI SSVPIGYSHP ALLKLIQQPQ NASMFVNRPA LGILPPENFV EKLRQSLLSV APKGMSQLIT MACGSCSNEN ALKTIFMWYR SKERGQRGFS QEELETCMIN QAPGCPDYSI LSFMGAFHGR TMGCLATTHS KAIHKIDIPS FDWPIAPFPR LKYPLEEFVK ENQQEEARCL EEVEDLIVKY RKKKKTVAGI IVEPIQSEGG DNHASDDFFR KLRDIARKHG CAFLVDEVQT GGGCTGKFWA HEHWGLDDPA DVMTFSKKMM TGGFFHKEEF RPNAPYRIFN TWLGDPSKNL LLAEVINIIK REDLLNNAAH AGKALLTGLL DLQARYPQFI SRVRGRGTFC SFDTPDDSIR NKLILIARNK GVVLGGCGDK SIRFRPTLVF RDHHAHLFLN IFSDILADFK TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | ABAT 4-aminobutyrate aminotransferase [ Homo sapiens (human) ] |
| Official Symbol : | ABAT |
| Synonyms : | ABAT; 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, mitochondrial; 4 aminobutyrate transaminase; GABAT; GABA transferase; GABA transaminase; GABA aminotransferase; 4-aminobutyrate transaminase; gamma-amino-N-butyrate transaminase; (S)-3-amino-2-methylpropionate transaminase; NPD009; GABA-AT; FLJ17813; FLJ30272; |
| Gene ID : | 18 |
| mRNA Refseq : | NM_000663 |
| Protein Refseq : | NP_000654 |
| MIM : | 137150 |
| UniProt ID : | P80404 |
◆ Recombinant Protein
| Abat-1459M | Recombinant Mouse Abat Protein, Myc/DDK-tagged | +Inquiry |
| ABAT-1106H | Recombinant Human ABAT Protein, His-SUMO/MYC-tagged | +Inquiry |
| ABAT-392R | Recombinant Rat ABAT Protein | +Inquiry |
| Abat-1035M | Recombinant Mouse Abat protein, His & T7-tagged | +Inquiry |
| ABAT-1034H | Recombinant Human ABAT protein, His & T7-tagged | +Inquiry |
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◆ Lysates
| ABAT-9153HCL | Recombinant Human ABAT 293 Cell Lysate | +Inquiry |
| ABAT-9154HCL | Recombinant Human ABAT 293 Cell Lysate | +Inquiry |
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