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Recombinant Human ACVR2B Protein, MYC/DDK-tagged

Cat.No. : ACVR2B-1155H
Product Overview : Recombinant human ACVR2B protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 57.5 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ACVR2B activin A receptor, type IIB [ Homo sapiens ]
Official Symbol : ACVR2B
Synonyms : ActR-IIB; ACTRIIB; HTX4
Gene ID : 93
mRNA Refseq : NM_001106
Protein Refseq : NP_001097
MIM : 602730
UniProt ID : Q13705

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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