Recombinant Human ADAP1 Protein, GST-Tagged
Cat.No. : | ADAP1-0005H |
Product Overview : | Human CENTA1 full-length ORF (NP_006860.1, 1 a.a. - 374 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | ADAP1 (ArfGAP With Dual PH Domains 1) is a Protein Coding gene. Among its related pathways are Arf6 signaling events and Class I PI3K signaling events. GO annotations related to this gene include GTPase activator activity and inositol 1,3,4,5 tetrakisphosphate binding. An important paralog of this gene is ADAP2. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 69.8 kDa |
AA Sequence : | MAKERRRAVLELLQRPGNARCADCG APDPDWASYTLGVFICLSCSGIHRN IPQVSKVKSVRLDAWEEAQVEFMAS HGNDAARARFESKVPSFYYRPTPSD CQLLREQWIRAKYERQEFIYPEKQE PYSAGYREGFLWKRGRDNGQFLSRK FVLTEREGALKYFNRNDAKEPKAVM KIEHLNATFQPAKIGHPHGLQVTYL KDNSTRNIFIYHEDGKEIVDWFNAL RAARFHYLQVAFPGASDADLVPKLS RNYLKEGYMEKTGPKQTEGFRKRWF TMDDRRLMYFKDPLDAFARGEVFIG SKESGYTVLHGFPPSTQGHHWPHGI TIVTPDRKFLFACETESDQREWVAA FQKAVDRPMLPQEYAVEAHFKHKP |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ADAP1 ArfGAP with dual PH domains 1 [ Homo sapiens ] |
Official Symbol : | ADAP1 |
Synonyms : | ADAP1; ArfGAP with dual PH domains 1; CENTA1, centaurin, alpha 1; arf-GAP with dual PH domain-containing protein 1; GCS1L; cnt-a1; centaurin-alpha; centaurin-alpha-1; centaurin, alpha 1; putative MAPK-activating protein PM25; CENTA1; p42IP4; |
Gene ID : | 11033 |
mRNA Refseq : | NM_006869 |
Protein Refseq : | NP_006860 |
MIM : | 608114 |
UniProt ID : | O75689 |
Products Types
◆ Recombinant Protein | ||
ADAP1-1149H | Recombinant Human ADAP1 Protein, MYC/DDK-tagged | +Inquiry |
Adap1-1534M | Recombinant Mouse Adap1 Protein, Myc/DDK-tagged | +Inquiry |
ADAP1-2483H | Recombinant Human ADAP1 protein, GST-tagged | +Inquiry |
ADAP1-5675H | Recombinant Human ADAP1 protein, His & T7-tagged | +Inquiry |
ADAP1-3615H | Recombinant Human ADAP1, His-tagged | +Inquiry |
◆ Lysates | ||
ADAP1-335HCL | Recombinant Human ADAP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (12)
Ask a questionTo be successful, ADAP1-based therapies will need to overcome several challenges. These include the specificity of its activity and potential off-target effects, determining optimal dosing and route of administration, and ensuring the therapies are safe and effective. Additionally, regulatory approval and commercialization of such therapies may also be challenging.
ADAP1-based therapies could have several potential benefits compared to current treatments. They could target specific pathways involved in certain diseases, potentially improving treatment effectiveness while minimizing side effects. Additionally, ADAP1-based therapies may have broader applications than current treatments, potentially being effective for multiple diseases.
ADAP1 protein is being explored for its potential therapeutic applications in various fields, including cancer therapy, neurodegenerative diseases, cardiovascular diseases, and immune-related disorders. Its involvement in the regulation of cell signaling pathways and synaptic plasticity may make it a promising target for the development of therapies to treat these conditions.
ADAP1 protein has potential applications in medicine for conditions related to cell signaling, synaptic plasticity, and the immune system. It could be used to develop therapies for neurological disorders such as Alzheimer's, schizophrenia, and epilepsy. It could also be used in immunotherapy to modulate immune cell activity and improve the efficacy of cancer treatment.
Yes, ADAP1 protein is involved in the regulation of the immune system. It plays a role in the activation and differentiation of T cells, as well as the production of cytokines and chemokines involved in the immune response. Additionally, ADAP1 may be involved in the regulation of immune checkpoints, which are important modulators of immune cell activation and antigen recognition.
ADAP1 protein may have potential as a target for the development of cancer therapies. It has been shown to play a role in regulating cell proliferation and migration, and its expression is often altered in cancer cells. Additionally, ADAP1 may play a role in the regulation of tumor angiogenesis and immune evasion, making it a potential target for the development of combination therapies.
One challenge associated with the development of ADAP1-based therapies is the specificity of its activity and potential off-target effects. ADAP1 protein interacts with many signaling proteins in the cell, some of which may have overlapping functions or play a role in normal physiological processes. Thus, it is important to develop selective inhibitors or modulators of ADAP1 activity to avoid unwanted side effects. Additionally, the optimal dosing and route of administration for ADAP1-based therapies remains to be determined through further research.
There is some evidence to suggest that ADAP1 protein may have potential as a therapeutic target for the treatment of cardiovascular diseases, such as hypertension and atherosclerosis. Its involvement in the regulation of cell signaling pathways that are involved in vascular remodeling and inflammation could make it a promising target for the development of small molecule inhibitors or biologic agents. However, additional research is needed to evaluate the safety and efficacy of these therapies.
ADAP1 protein may have potential as a therapeutic agent for the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It has been shown to play a role in regulating synaptic function and plasticity, which are critical for maintaining normal cognitive function and behavior. Additionally, ADAP1 may play a role in the regulation of oxidative stress, inflammation, and cell death, which are all involved in the pathogenesis of neurodegenerative diseases.
Currently, there are no clinical trials investigating the therapeutic potential of ADAP1 protein. However, preclinical studies are ongoing to evaluate its safety and efficacy in various applications, including cancer therapy and neurodegenerative diseases. Additional research is needed to determine the potential benefits and optimal dosing regimens for ADAP1-based therapies.
ADAP1-based therapies are still in the early stages of development. There are some studies exploring the potential of ADAP1 protein as a therapeutic target, but no ADAP1-based therapies have been approved for clinical use yet. Further research is needed to determine the safety and efficacy of ADAP1-based therapies.
ADAP1 protein binds to and regulates the activity of various proteins involved in cell signaling pathways, such as the protein kinase C (PKC) family and the small GTPase RhoA. It can either activate or inhibit these proteins depending on its binding partners and cellular context, thus modulating downstream signaling pathways involved in many cellular processes, such as cell proliferation, migration, and survival.
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