| Species : |
Human |
| Source : |
Sf9 Cells |
| Tag : |
Flag |
| Protein Length : |
2-741 aa |
| Description : |
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. |
| Purity : |
>85% |
| Stability : |
1 year at –70 centigrade from date of shipment. |
| Storage : |
Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Storage Buffer : |
Recombinant protein stored in 50mM Tris, pH7.5 150mM NaCl, 1mM EDTA, 0.5 mg/mL Flagtide, 1mM DTT, 10% glycerol. |
| Concentration : |
0.18 μg/μL |
| Shipping : |
Dry ice |
| Reference : |
1. Hajji, H. et al.: ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations. RNA. 2022; 28(10):1281-1297.
2. Iwamoto, K. et al.: Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies. RNA Biol. 2009; 6: 248–253. |
