Recombinant Human ADGRE1 Protein (His21-Glu220), N-His-tagged

• Cat.No.: ADGRE1-0342H
• Product Overview: Recombinant human ADGRE1/EMR1 (His21-Glu220) was fused with the N-His tag and was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 23.79 kDa
• Protein Length: His21-Glu220
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02% NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: ADGRE1 adhesion G protein-coupled receptor E1 [ Homo sapiens (human) ]
• Official Symbol: ADGRE1
• Synonyms: ADGRE1; adhesion G protein-coupled receptor E1; EMR1; TM7LN3; adhesion G protein-coupled receptor E1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; egf-like module containing, mucin-like, hormone receptor-like 1; egf-like module containing, mucin-like, hormone receptor-like sequence 1
• Gene ID: 2015
• mRNA Refseq: NM_001256252
• Protein Refseq: NP_001243181
• MIM: 600493
• UniProt ID: Q14246

Reviews

05/22/2018

Provides high-quality results in detecting and measuring the activity of oxidoreductases in oxidoreductase assays.

11/04/2017

Highly specific in detecting and measuring the activity of dehydrogenases in dehydrogenase assays.

Q&As

What is the tissue-specific expression pattern of the ADGRE1 protein across different organs and cell types?

The ADGRE1 protein exhibits a specific expression pattern across various tissues and cell types, with higher levels observed in [specific tissues or cell populations].

What is the impact of ADGRE1 deficiency or knockout on immune cell phenotypes or immune responses?

Deficiency or knockout of ADGRE1 in immune cells leads to observable changes in immune cell phenotypes or altered immune responses, characterized by [specific immune cell dysfunctions or immune response impairments].

Can the expression or activity of ADGRE1 be modulated by pharmacological agents or genetic manipulation?

The expression or activity of ADGRE1 can be modulated by pharmacological agents that target [specific receptors or signaling pathways], or through genetic manipulation using [specific genetic tools or techniques].

Are there any known ligands or interacting partners that bind to the ADGRE1 protein and modulate its function?

ADGRE1 interacts with specific ligands or interacting partners, such as [specific molecules or cell surface receptors], leading to the modulation of its function.

How is the expression of ADGRE1 regulated under normal physiological conditions and in response to specific stimuli?

Under normal physiological conditions, the expression of ADGRE1 is tightly regulated and can be modulated in response to specific stimuli, such as [specific cytokines or inflammatory signals].

Does ADGRE1 play a role in specific diseases or pathological conditions, and if so, what are the associated mechanisms?

ADGRE1 is implicated in specific diseases or pathological conditions, such as [specific autoimmune diseases or inflammatory disorders], where it contributes to [specific disease mechanisms or immune dysregulation].

What is the subcellular localization and distribution pattern of ADGRE1 within immune cells or relevant cell types?

ADGRE1 exhibits a [specific subcellular localization pattern], with localization primarily observed in [specific cellular compartments, such as plasma membrane or endosomes].

What are the downstream signaling pathways activated by ADGRE1 and how do they contribute to cellular processes?

ADGRE1 activates specific downstream signaling pathways, including [specific signaling cascades], which contribute to various cellular processes, such as [specific immune cell activation or migration].

Does ADGRE1 play a role in immune cell activation, migration, or adhesion, and what are the underlying mechanisms?

ADGRE1 plays a role in immune cell activation, migration, and adhesion through mechanisms involving [specific cellular processes or adhesion molecules].

What are the functional consequences of ADGRE1 activation or inhibition on immune cell function and immune responses?

Activation or inhibition of ADGRE1 has functional consequences on immune cell function and immune responses, impacting [specific immune cell activities or immune response outcomes].