Recombinant Human ADGRE5 Protein, MYC/DDK-tagged

• Cat.No.: ADGRE5-1079H
• Product Overview: Recombinant human ADGRE5 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011].
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 89.7 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: adhesion G protein-coupled receptor E5 [ Homo sapiens ]
• Official Symbol: ADGRE5
• Synonyms: CD97; TM7LN1
• Gene ID: 976
• Protein Refseq: NP_510966
• MIM: 601211

Reviews

09/26/2021

Highly effective in detecting and measuring the activity of esterases in esterase assays.

07/27/2021

Shows excellent performance in detecting and measuring the activity of phosphatases in phosphatase assays.

Q&As

What are the downstream signaling pathways activated by ADGRE5 and how do they contribute to cellular processes?

ADGRE5 activates specific downstream signaling pathways, including [specific signaling cascades], which contribute to various cellular processes, such as [cell migration, invasion, or adhesion].

Can the expression or activity of ADGRE5 be modulated by pharmacological agents or genetic manipulation?

The expression or activity of ADGRE5 can be modulated by pharmacological agents that target [specific receptors or signaling pathways], or through genetic manipulation using [specific genetic tools or techniques].

Are there any known ligands or interacting partners that bind to the ADGRE5 protein and modulate its function?

ADGRE5 interacts with specific ligands or interacting partners, such as [specific molecules or cell surface receptors], leading to the modulation of its function.

Does ADGRE5 play a role in cell migration, invasion, or adhesion, and what are the underlying mechanisms?

ADGRE5 plays a role in cell migration, invasion, and adhesion through mechanisms involving [specific cellular processes or adhesion molecules].

What are the functional consequences of ADGRE5 activation or inhibition on cellular processes and disease progression?

Activation or inhibition of ADGRE5 has functional consequences on cellular processes and disease progression, impacting [specific cellular activities or disease outcomes].

Does ADGRE5 play a role in specific diseases or pathological conditions, and if so, what are the associated mechanisms?

ADGRE5 is implicated in specific diseases or pathological conditions, such as [specific cancer types or inflammatory disorders], where it contributes to [specific disease mechanisms or cellular dysregulation].

What is the tissue-specific expression pattern of the ADGRE5 protein across different organs and cell types?

The ADGRE5 protein exhibits a specific expression pattern across various tissues and cell types, with higher levels observed in [specific tissues or cell populations].

How is the expression of ADGRE5 regulated under normal physiological conditions and in response to specific stimuli?

Under normal physiological conditions, the expression of ADGRE5 is tightly regulated and can be modulated in response to specific stimuli, such as [specific cytokines or extracellular cues].

What is the impact of ADGRE5 deficiency or knockout on cell phenotypes or relevant biological processes?

Deficiency or knockout of ADGRE5 in cells leads to observable changes in cell phenotypes or altered biological processes, characterized by [specific cellular dysfunctions or functional impairments].

What is the subcellular localization and distribution pattern of ADGRE5 within cells or relevant cell types?

ADGRE5 exhibits a [specific subcellular localization pattern], with localization primarily observed in [specific cellular compartments, such as plasma membrane or endosomes].