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Recombinant Human ADPRH Protein, GST-tagged

Cat.No. : ADPRH-374H
Product Overview : Human ADPRH full-length ORF ( NP_001116.1, 1 a.a. - 357 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 65.9 kDa
AA Sequence : MEKYVAAMVLSAAGDALGYYNGKWE FLQDGEKIHRQLAQLGGLDALDVGR WRVSDDTVMHLATAEALVEAGKAPK LTQLYYLLAKHYQDCMEDMDGRAPG GASVHNAMQLKPGKPNGWRIPFNSH EGGCGAAMRAMCIGLRFPHHSQLDT LIQVSIESGRMTHHHPTGYLGALAS ALFTAYAVNSRPPLQWGKGLMELLP EAKKYIVQSGYFVEENLQHWSYFQT KWENYLKLRGILDGESAPTFPESFG VKERDQFYTSLSYSGWGGSSGHDAP MIAYDAVLAAGDSWKELAHRAFFHG GDSDSTAAIAGCWWGVMYGFKGVSP SNYEKLEYRNRLEETARALYSLGSK EDTVISL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADPRH ADP-ribosylarginine hydrolase [ Homo sapiens ]
Official Symbol : ADPRH
Synonyms : ADPRH; ADP-ribosylarginine hydrolase; [Protein ADP-ribosylarginine] hydrolase; ARH1; ADP-ribose-L-arginine cleaving enzyme;
Gene ID : 141
mRNA Refseq : NM_001125
Protein Refseq : NP_001116
MIM : 603081
UniProt ID : P54922

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Can changes in the ADPRH gene lead to disease? 12/10/2021

Yes, genetic variations in the ADPRH gene have been associated with several diseases. For example, a single nucleotide polymorphism (SNP) in the ADPRH gene has been linked to an increased risk of systemic lupus erythematosus (SLE), an autoimmune disease that affects multiple organs in the body. Another SNP in the ADPRH gene has been associated with an increased risk of developing age-related macular degeneration, a common eye disease that can lead to vision loss. In addition, mutations in the ADPRH gene have been identified in patients with intellectual disability and developmental delay, although the underlying mechanisms are not fully understood.

Are there any ADPRH-targeted therapies in development? 04/30/2021

There are currently no ADPRH-targeted therapies approved for clinical use. However, ADPRH inhibitors have been developed as potential anticancer agents, and several compounds have shown promising results in preclinical studies. These inhibitors may work by disrupting DNA damage repair pathways or promoting cell death in cancer cells. In addition, modulation of ADPRH activity is being investigated as a potential therapeutic approach for neurodegenerative diseases and immune disorders, although more research is needed in these areas.

How is ADPRH studied in the laboratory? 11/09/2019

ADPRH can be studied in the laboratory using a variety of techniques, including molecular biology, biochemistry, and cell biology approaches. These may involve cloning and expressing ADPRH in bacterial or eukaryotic cells, purifying the protein to determine its structure and enzymatic activity, or using gene knockdown or overexpression techniques to investigate its function in cells or animal models. In addition, high-throughput screening methods such as chemical compound libraries can be used to identify small molecules that modulate ADPRH activity or expression.

What are the medical implications of ADPRH dysregulation? 05/23/2019

Dysregulation of ADPRH expression or activity has been associated with several diseases, including cancer, neurodegeneration, and immune disorders. For example, ADPRH may act as a tumor suppressor by participating in DNA repair pathways and preventing the accumulation of genomic mutations. Loss of ADPRH activity has been observed in several cancer types, including breast cancer and leukemia. In neurodegenerative diseases such as Alzheimer's and Parkinson's disease, ADPRH may play a role in regulating oxidative stress and cell death pathways. In addition, ADPRH has been implicated in modulating immune responses, and dysregulation of ADPRH activity may contribute to autoimmune diseases such as systemic lupus erythematosus.

Can ADPRH be used as a diagnostic biomarker? 12/27/2016

There is currently limited evidence to support the use of ADPRH as a diagnostic biomarker. However, some studies have suggested that ADPRH expression levels may be altered in certain diseases, such as cancer, and could potentially be used as a diagnostic or prognostic biomarker. For example, low ADPRH expression has been associated with a poor prognosis in breast cancer patients, suggesting that it may serve as a useful biomarker for predicting patient outcomes. Further research is needed to validate the utility of ADPRH as a biomarker in different disease contexts.

Is there a relationship between ADPRH and PARP inhibitors? 01/28/2016

Yes, ADPRH and PARP (poly ADP-ribose polymerase) enzymes are both involved in the metabolism of ADP-ribose and play key roles in DNA damage repair pathways. PARP inhibitors are a class of drugs that inhibit the enzymatic activity of PARP enzymes and have been used as a targeted therapy in several cancer types, particularly in cancers with defects in DNA repair mechanisms. However, recent studies have suggested that ADPRH can compensate for the loss of PARP enzymes in repairing single-strand DNA breaks, and that combination therapies targeting both ADPRH and PARP might provide greater therapeutic benefit than PARP inhibitors alone. Further research is needed to explore the potential of dual targeting of ADPRH and PARP as a treatment strategy in cancer and other diseases.

What are the physiological consequences of ADPRH deficiency? 01/27/2016

ADPRH deficiency has been associated with several pathological conditions, including cancer, neurodegeneration, and immune dysfunction. In humans, mutations in the ADPRH gene have been found in individuals with hereditary sensory and autonomic neuropathy type IX (HSAN-IX), a rare disorder characterized by progressive degeneration of peripheral sensory and autonomic neurons. These mutations affect the enzymatic activity of ADPRH and result in the accumulation of ADP-ribose conjugates and increased sensitivity to DNA damage. ADPRH deficiency has also been linked to cancer, as decreased expression of ADPRH has been observed in various types of cancer cells, suggesting a potential tumor suppressor role. Additionally, recent studies have shown that ADPRH modulates the immune response by regulating the activity of cytokines and chemokines, indicating a role in immune homeostasis and inflammation. These findings suggest that ADPRH deficiency may contribute to the development of various diseases and highlight the importance of ADPRH in maintaining cellular and organismal health.

Customer Reviews (4)

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Reviews
08/12/2022

    I appreciate the manufacturer's commitment to quality and their willingness to work with me to customize the product to meet my specific needs.

    01/24/2022

      The manufacturer's exceptional technical support has helped me to resolve any issues I encountered promptly and efficiently, which has been invaluable to my research.

      08/06/2020

        The product meets my requirements and performs beyond expectations in my experiments.

        03/15/2019

          the protein's high purity and activity have allowed me to achieve consistent and reliable results in my assays.

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