Recombinant Human AHCYL1, His-tagged

• Cat.No.: AHCYL1-8459H
• Product Overview: AHCY Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 452 amino acids (1-432 a.a.) and having a molecular mass of 49.8 kDa. The AHCY is fused to 20 amino acid His-Tag at N-terminus and purified by chromatogra

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-432 a.a.
• Description: AHCY is an enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). AHCY controls the intracellular S-adenosylhomocysteine (SAH) concentration that is crucial for transmethylation reactions. AHCY deficiency causes hypermethioninemia.
• Form: Sterile filtered solution in 20 mM Tris, pH 8 with 10 % glycerol.
• Molecular Mass: 49.8 kDa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMRERYSASKPLKGARI AGCLHMTVET AVLIETLVTL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVYAWKGETDEEY LWCIEQTLYF KDGPLNMILD DGGDLTNLIH TKYPQLLPGI RGISEETTTGVHNLYKMMAN GILKVPAINV NDSVTKSKFD NLYGCRESLI DGIKRATDVM IA
• Purity: ≥95% by SDS - PAGE
• Storage: Store at -20°C. Avoid freeze-thaw cycles.
• Shipping: Blue Ice

Gene Information

• Gene Name: AHCYL1 adenosylhomocysteinase-like 1 [ Homo sapiens ]
• Official Symbol: AHCYL1
• Synonyms: AHCYL1; adenosylhomocysteinase-like 1; S adenosylhomocysteine hydrolase like 1; putative adenosylhomocysteinase 2; inositol 1; 4; 5 trisphosphate receptor binding protein; IRBIT; XPVKONA; adoHcyase 2; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosyl homocysteine hydrolase homolog; dendritic cell expressed AHCY-like protein; S-adenosylhomocysteine hydrolase-like protein 1; inositol 1,4,5-trisphosphate receptor-binding protein; DCAL; PRO0233
• Gene ID: 10768
• mRNA Refseq: NM_001242673
• Protein Refseq: NP_001229602
• MIM: 607826
• UniProt ID: O43865
• Chromosome Location: 1p13
• Pathway: Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserved biosystem; cysteine biosynthesis III (mammalia), organism-specific biosystem; methionine degradation I (to homocysteine), organism-specific biosystem
• Function: adenosylhomocysteinase activity; hydrolase activity