Recombinant Human AIFM2 Protein, His-tagged
Cat.No. : | AIFM2-016H |
Product Overview : | Active recombinant N-terminal His-tagged human FSP1 protein (2-373) was expressed in E. coli. |
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Description : | This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 42.5 kDa |
Protein length : | 2-373 |
Purity : | ≥70% estimated by SDS-PAGE |
Unit Definition : | One unit is defined as the amount of enzyme required to produce 1 nmol of NAD+ per minute at 25 centigrade in 25 mM Tris-HCl, pH 7.4, with 150 mM sodium chloride and 200 μM coenzyme Q1. |
Applications : | Enzyme assay |
Stability : | ≥ 2 years |
Storage : | At -80 centigrade. |
Storage Buffer : | 50 mM potassium phosphate, pH 7.8, with 200 mM sodium chloride, 10% glycerol, and 0.1 mM TCEP |
Gene Name : | AIFM2 apoptosis inducing factor mitochondria associated 2 [ Homo sapiens (human) ] |
Official Symbol : | AIFM2 |
Synonyms : | AIFM2; apoptosis inducing factor mitochondria associated 2; AMID; FSP1; PRG3; ferroptosis suppressor protein 1; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; apoptosis-inducing factor, mitochondrion-associated, 2; p53-responsive gene 3 protein |
Gene ID : | 84883 |
mRNA Refseq : | NM_032797 |
Protein Refseq : | NP_116186 |
MIM : | 605159 |
UniProt ID : | Q9BRQ8 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewTheir prompt and reliable assistance enables me to navigate through protocols, troubleshoot issues, and interpret complex data, ensuring the successful completion of my research goals.
the exceptional quality of the AIFM2 protein, combined with the manufacturer's exceptional technical support, positions it as an invaluable asset for my experimental endeavors.
With their extensive knowledge and expertise, they are well-equipped to address any challenges or inquiries that may arise during my experiments.
Q&As (12)
Ask a questionAIFM2 inhibitors are compounds that inhibit the activity of AIFM2 protein. These inhibitors are being developed as potential therapeutics for diseases such as cancer and neurodegenerative disorders. In research, AIFM2 inhibitors are used to study the role of AIFM2 in cellular processes and to investigate the effects of inhibiting AIFM2 activity on disease outcomes.
Yes, changes in AIFM2 expression levels have been associated with several disease states. For example, decreased expression of AIFM2 has been linked with increased oxidative stress and mitochondrial dysfunction, which are both implicated in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
Yes, AIFM2 protein has been shown to play a role in neuronal death and neurodegenerative diseases. AIFM2 is localized in the mitochondria and is involved in regulating mitochondrial function, which is critical for maintaining neuronal homeostasis. Dysregulation of AIFM2 has been observed in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, and has been associated with neuronal death.
AIFM2 expression is regulated at the transcriptional level by various transcription factors, including ATF4 and GABP. It can also be regulated at the post-transcriptional level by microRNAs, which can target the AIFM2 mRNA for degradation or inhibit its translation. In addition, AIFM2 expression can be influenced by cellular stress and disease states, which can impact its localization and activity.
The dysregulation of AIFM2 in neurodegenerative diseases implicates it as a potential therapeutic target. Targeting AIFM2 activity could potentially attenuate the neuronal death and degeneration observed in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. AIFM2 inhibitors are being developed as potential therapeutics for these conditions.
AIFM2 protein has been shown to play a role in cancer by regulating apoptosis and cell survival. Decreased expression of AIFM2 has been observed in several types of cancer, including breast, prostate, and colon cancer. This decreased expression is thought to contribute to the development and progression of cancer by inhibiting apoptosis and promoting cell survival.
The activity of AIFM2 protein is regulated by its subcellular localization, post-translational modifications, and interaction with other proteins. The protein contains a conserved N-terminal mitochondrial targeting sequence that directs it to the mitochondria. The activity of AIFM2 protein can be regulated by phosphorylation, acetylation, and S-nitrosylation, as well as by the binding of other proteins.
Yes, AIFM2 protein is a potential therapeutic target for several diseases, including neurodegenerative disorders and cancer. Strategies such as small molecule inhibitors or gene therapy to regulate AIFM2 activity could be explored as potential therapeutic approaches. However, further research is needed to assess the safety and efficacy of such interventions.
Yes, several genetic mutations have been identified in the AIFM2 gene that are associated with diseases. For example, a mutation in the AIFM2 gene has been linked to an autosomal recessive disorder characterized by deafness, optic neuropathy, and muscle weakness.
AIFM2 protein has been identified as a potential biomarker for several diseases, including neurodegenerative disorders and cancer. Changes in AIFM2 expression levels have been observed in these diseases, and measuring AIFM2 levels in biological samples such as blood or cerebrospinal fluid may provide a non-invasive way to monitor disease progression or response to treatment.
Yes, AIFM2 has emerged as a potential target for cancer therapy. Modulating AIFM2 expression or activity has been shown to impact cancer cell survival and proliferation, and AIFM2 inhibitors are being developed as potential therapeutics. Clinical trials are ongoing to evaluate the safety and efficacy of these inhibitors in cancer patients.
AIFM2 plays a role in regulating oxidative stress in cells. It is involved in maintaining mitochondrial function and regulating ROS levels. Dysregulation of AIFM2 has been associated with increased cellular oxidative stress, which can contribute to the pathogenesis of various diseases such as cancer and neurodegenerative disorders.
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