Recombinant Human AIM2 Protein, GST-tagged

• Cat.No.: AIM2-478H
• Product Overview: Human AIM2 full-length ORF ( AAH10940, 1 a.a. - 356 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 64.9 kDa
• AA Sequence: MESKYKEILLLTGLDNITDEELDRF KFFLSDEFNIATGKLHTANRIQVAT LMIQNAGAVSAVMKTIRIFQKLNYM LLAKRLQEEKEKVDKQYKSVTKPKP LSQAEMSPAASAAIRNDVAKQRAAP KVSPHVKPEQKQMVAQQESIREGFQ KRCLPVMVLKAKKPFTFETQEGKQE MFHATVATEKEFFFVKVFNTLLKDK FIPKRIIIIARYYRHSGFLEVNSAS RVLDAESDQKVNVPLNVIRKAGETP KINTLQTQPLGTIVNGLFVVQKVTE KKKNILFDLSDNTGKMEVLGVRNED TMKCKEGDKVRLTFFTLSKNGEKLQ LTSGVHSTIKVIKAKKKKHREVKRT NSSQLV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AIM2 absent in melanoma 2 [ Homo sapiens ]
• Official Symbol: AIM2
• Synonyms: AIM2; absent in melanoma 2; interferon-inducible protein AIM2; PYHIN4
• Gene ID: 9447
• mRNA Refseq: NM_004833
• Protein Refseq: NP_004824
• MIM: 604578
• UniProt ID: O14862

Reviews

05/29/2019

The AIM2 protein exemplifies unparalleled quality, making it an ideal candidate to fulfill my experimental requirements.

04/05/2016

this protein propels my investigations forward, paving the way for groundbreaking breakthroughs and advancements in my specific field of study.

04/15/2015

The AIM2 protein, complemented by the manufacturer's exceptional technical support, equips me with the confidence and assurance needed to face my experimental problems head-on.

Q&As

Can AIM2 protein be used to develop new cancer therapies?

AIM2 protein has been studied as a potential target for developing new cancer therapies, particularly for tumors that exhibit high levels of AIM2 expression. One approach is to deliver drugs or other therapies directly to cancer cells that have high levels of AIM2 expression, which could selectively kill those cells while sparing healthy cells. Another approach is to use immunotherapy to stimulate the immune system to attack cancer cells that express high levels of AIM2. While these approaches are still in the early stages of development, they have shown promise in preclinical studies.

Can AIM2 protein be used as a biomarker for disease diagnosis or prognosis?

The potential use of AIM2 protein as a biomarker for disease diagnosis or prognosis is still being studied. Some studies have suggested that elevated levels of AIM2 protein may be associated with increased risk of certain cancers and other diseases, but more research is needed to determine the potential utility of AIM2 protein as a biomarker.

What are the potential limitations or challenges with targeting AIM2 protein for therapy?

One challenge with targeting AIM2 for therapy is the potential for inducing inflammation and tissue damage if the immune response is not precisely regulated. Additionally, the role of AIM2 protein in various disease states is still being researched, and more information is needed to determine the most effective strategies for targeting AIM2-mediated processes.

How does the expression of AIM2 protein change with age?

Studies have shown that the expression of AIM2 protein and other inflammasome components can change with age, leading to an increased inflammatory response and a higher risk of age-related diseases such as Alzheimer's disease and cardiovascular disease. This age-related dysregulation of the inflammasome has been attributed to a number of factors, including changes in epigenetic regulation, accumulation of DNA damage, and alterations in cellular metabolism. Understanding how the inflammasome changes with age may lead to new strategies for promoting healthy aging.

Are there any therapeutic agents that target AIM2 protein?

Several therapeutic agents aimed at targeting AIM2 protein are currently being explored, including small molecule inhibitors and anti-inflammatory drugs such as colchicine and methotrexate. Additionally, some studies have shown that dietary factors such as curcumin may modulate AIM2-mediated responses. However, more research is needed to determine the safety and efficacy of these agents for therapeutic use in humans.

Is there any research on the potential therapeutic applications of AIM2 protein?

There is significant interest in the potential therapeutic applications of AIM2 protein, particularly in the treatment of cancer. AIM2 is also being studied as a therapeutic target for various inflammatory and autoimmune diseases.

What are the diseases associated with AIM2 protein?

AIM2 protein has been implicated in a range of autoimmune and inflammatory diseases, including lupus, rheumatoid arthritis, and diabetes. AIM2 is also thought to play a role in the pathogenesis of atherosclerosis and Alzheimer's disease.

Is there any association between AIM2 protein and autoimmune diseases?

There is evidence to suggest that AIM2 protein plays a role in the development of autoimmune diseases such as lupus, rheumatoid arthritis, and Sjogren's syndrome. Some studies have shown that levels of AIM2 protein are elevated in patients with these conditions, although more research is needed to fully understand the underlying mechanisms.

Can AIM2 protein be used as a biomarker for disease?

Yes, AIM2 protein has been studied as a potential biomarker for a variety of diseases, including cancer, inflammatory bowel disease, and autoimmune disorders. Studies have shown that levels of AIM2 protein and its associated inflammasome components may be altered in these diseases, suggesting that AIM2 could be used as a diagnostic or prognostic marker. However, further research is needed to validate these findings and determine the clinical utility of AIM2 as a biomarker.

Are there any dietary factors that can affect AIM2 expression?

Studies have shown that certain dietary factors can affect AIM2 expression and inflammasome activation. For example, consumption of a high-fat diet has been linked to increased inflammasome activation and AIM2 expression in the liver, which can contribute to the development of non-alcoholic fatty liver disease (NAFLD). On the other hand, diets rich in fiber and other types of plant-based foods have been shown to decrease inflammasome activation and reduce AIM2 expression in the gut, which can help to prevent inflammatory bowel disease.

How is AIM2 protein involved in antiviral immune response?

AIM2 protein plays a critical role in the antiviral immune response by detecting the presence of viral DNA in the cytoplasm and initiating the inflammasome-mediated production of pro-inflammatory cytokines to eliminate the virus. Studies have shown that AIM2 activation is important for controlling viral infections such as herpes simplex virus, vaccinia virus, and others.

How does AIM2 protein contribute to inflammasome activation?

AIM2 protein functions as a cytoplasmic DNA sensor that detects the presence of DNA from various sources, including viruses and bacteria. Once activated, AIM2 recruits and activates the adaptor protein ASC, which then recruits and activates the inflammatory enzyme caspase-1, leading to the production of pro-inflammatory cytokines and other mediators. This process is known as inflammasome activation and is critical for initiating the inflammatory response necessary for host defense against pathogens and other threats.

Are there any drugs that target AIM2 protein?

Currently, there are no drugs that specifically target AIM2 protein. However, some drugs have been shown to inhibit inflammasome activation, a pathway in which AIM2 is involved. These drugs, such as colchicine and canakinumab, are used to treat inflammatory diseases such as gout and Familial Mediterranean Fever (FMF) by decreasing the release of pro-inflammatory cytokines produced by inflammasome activation.

Are there any genetic disorders associated with AIM2 protein mutations?

Yes, there are several genetic disorders associated with AIM2 protein mutations. One such disorder is called familial Mediterranean fever (FMF), which is characterized by recurrent episodes of fever and inflammation in the abdomen, lungs, joints, and skin. FMF is caused by mutations in a gene called MEFV, which encodes a protein called pyrin that interacts with AIM2 to regulate inflammasome activation and inflammation.