Recombinant Human AKR1C4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: AKR1C4-1269H
• Product Overview: AKR1C4 MS Standard C13 and N15-labeled recombinant protein (NP_001809) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 37.2 kDa
• AA Sequence: MDPKYQRVELNDGHFMPVLGFGTYA PPEVPRNRAVEVTKLAIEAGFRHID SAYLYNNEEQVGLAIRSKIADGSVK REDIFYTSKLWCTFFQPQMVQPALE SSLKKLQLDYVDLYLLHFPMALKPG ETPLPKDENGKVIFDTVDLSATWEV MEKCKDAGLAKSIGVSNFNYRQLEM ILNKPGLKYKPVCNQVECHPYLNQS KLLDFCKSKDIVLVAHSALGTQRHK LWVDPNSPVLLEDPVLCALAKKHKR TPALIALRYQLQRGVVVLAKSYNEQ RIRENIQVFEFQLTSEDMKVLDGLN RNYRYVVMDFLMDHPDYPFSDEYTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: AKR1C4 aldo-keto reductase family 1 member C4 [ Homo sapiens (human) ]
• Official Symbol: AKR1C4
• Synonyms: AKR1C4; aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4); CHDR; aldo-keto reductase family 1 member C4; 3 alpha HSD; C11; CDR; DD4; HAKRA; MGC22581; 3-alpha-HSD1; dihydrodiol dehydrogenase isozyme DD4; type I 3-alpha-hydroxysteroid dehydrogenase; DD-4; 3-alpha-HSD
• Gene ID: 1109
• mRNA Refseq: NM_001818
• Protein Refseq: NP_001809
• MIM: 600451
• UniProt ID: P17516