Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ALDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ALDH2-4336H
Product Overview : ALDH2 MS Standard C13 and N15-labeled recombinant protein (NP_000681) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
  • Related Products
Description : This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 56.4 kDa
AA Sequence : MLRAAARFGPRLGRRLLSAAATQAV PAPNQQPEVFCNQIFINNEWHDAVS RKTFPTVNPSTGEVICQVAEGDKED VDKAVKAARAAFQLGSPWRRMDASH RGRLLNRLADLIERDRTYLAALETL DNGKPYVISYLVDLDMVLKCLRYYA GWADKYHGKTIPIDGDFFSYTRHEP VGVCGQIIPWNFPLLMQAWKLGPAL ATGNVVVMKVAEQTPLTALYVANLI KEAGFPPGVVNIVPGFGPTAGAAIA SHEDVDKVAFTGSTEIGRVIQVAAG SSNLKRVTLELGGKSPNIIMSDADM DWAVEQAHFALFFNQGQCCCAGSRT FVQEDIYDEFVERSVARAKSRVVGN PFDSKTEQGPQVDETQFKKILGYIN TGKQEGAKLLCGGGIAADRGYFIQP TVFGDVQDGMTIAKEEIFGPVMQIL KFKTIEEVVGRANNSTYGLAAAVFT KDLDKANYLSQALQAGTVWVNCYDV FGAQSPFGGYKMSGSGRELGEYGLQ AYTEVKTVTVKVPQKNSTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ALDH2 aldehyde dehydrogenase 2 family member [ Homo sapiens (human) ]
Official Symbol : ALDH2
Synonyms : ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial; ALDH class 2; liver mitochondrial ALDH; acetaldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2; ALDM; ALDHI; ALDH-E2; MGC1806;
Gene ID : 217
mRNA Refseq : NM_000690
Protein Refseq : NP_000681
MIM : 100650
UniProt ID : P05091

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (17)

Ask a question
Are there any medications that interact with the ALDH2 protein variant? 11/12/2021

Yes, some medications can interact with the ALDH2*2 variant. Disulfiram (Antabuse), used to treat alcohol dependence, inhibits ALDH2 activity, leading to a buildup of acetaldehyde and causing severe adverse effects in individuals with the ALDH2*2 variant. Therefore, individuals with this variant should avoid medications that hinder ALDH2 activity.

Can the ALDH2 protein variant affect drug metabolism? 09/01/2021

Yes, the ALDH2*2 variant can impact drug metabolism. ALDH2 is involved in the metabolism of some medications, especially those containing aldehydes. Individuals with the variant may experience altered drug metabolism, potentially affecting the efficacy and safety of certain medications. It is essential for healthcare providers to consider this variant when prescribing medications to individuals with the ALDH2*2 variant.

What are the effects of the ALDH2 protein variant on alcohol metabolism? 06/24/2021

The ALDH2*2 variant affects the metabolism of alcohol by causing the accumulation of acetaldehyde in the body. This leads to facial flushing, rapid heartbeat, nausea, headache, and other uncomfortable symptoms when individuals with the variant consume alcohol.

Are there any treatments available for individuals with the ALDH2 protein variant? 04/29/2020

Currently, there is no specific treatment available to reverse or alter the ALDH2*2 variant. Management primarily involves avoiding alcohol consumption or minimizing intake to prevent the accumulation of acetaldehyde and the associated symptoms and health risks.

How is ALDH2 protein related to alcohol intolerance? 07/05/2019

ALDH2 protein is closely related to alcohol intolerance. Alcohol intolerance refers to the inability to metabolize acetaldehyde efficiently, leading to unpleasant symptoms after consuming even small amounts of alcohol. The ALDH2*2 variant reduces the enzyme's activity, causing acetaldehyde to accumulate and resulting in alcohol intolerance symptoms.

How can the ALDH2 protein variant be diagnosed? 03/22/2019

The ALDH2*2 variant can be diagnosed through genetic testing. A simple genetic test, usually done through a blood or saliva sample, can determine the presence of the variant. This test can be performed by a medical professional or a genetic testing service.

Can individuals with the ALDH2 protein variant safely consume any amount of alcohol? 02/04/2019

Individuals with the ALDH2*2 variant may experience severe adverse effects even with minimal alcohol consumption. Due to the buildup of acetaldehyde, it is generally advised that individuals with this variant limit their alcohol intake or avoid it altogether to prevent discomfort and potential health risks.

Can the ALDH2 protein variant be tested for? 11/25/2018

Yes, the ALDH2*2 variant can be detected through genetic testing. Genomic analysis can identify the presence of the genetic mutation associated with the variant. This testing can be beneficial in determining an individual's susceptibility to alcohol-related symptoms and tailor personalized recommendations for alcohol consumption.

Can the ALDH2 protein variant be inherited? 09/20/2018

Yes, the ALDH2*2 variant is inherited in an autosomal dominant manner. This means that if one parent carries the variant, there is a 50% chance of passing it on to their offspring. If both parents have the variant, the likelihood increases to 75%.

How does the ALDH2 protein variant affect its function? 07/11/2018

The ALDH2 protein variant, known as ALDH2*2, has a genetic mutation that reduces the activity of the enzyme. Individuals with this variant have a decreased ability to break down acetaldehyde, leading to a buildup of this toxic substance in their bodies when they consume alcohol.

Can individuals with the ALDH2 protein variant experience other symptoms besides alcohol intolerance? 06/12/2018

While alcohol intolerance is the most common symptom associated with the ALDH2*2 variant, individuals with the variant may also experience other symptoms related to acetaldehyde buildup, such as facial swelling, dizziness, rapid heartbeat, and increased blood pressure.

Are certain populations more likely to have the ALDH2 protein variant? 12/26/2017

The ALDH2*2 variant is most common in East Asian populations, such as those of Chinese, Japanese, and Korean descent. It is estimated that approximately 30-50% of East Asians carry at least one copy of the variant.

Are there any other conditions or diseases associated with the ALDH2 protein variant? 12/23/2017

In addition to alcohol-related health issues, the ALDH2*2 variant has been linked to an increased risk of esophageal cancer, particularly in individuals who consume alcohol. Chronic alcohol consumption, combined with the inability to efficiently metabolize acetaldehyde due to the variant, can cause significant damage to the esophagus and increase the likelihood of developing cancer.

Is there any ongoing research or treatments being developed for the ALDH2 protein variant? 08/17/2017

Currently, there is ongoing research to better understand the effects of the ALDH2*2 variant and its implications for health. In terms of treatments, while there is no specific cure for the variant, some studies are investigating potential therapeutic approaches to enhance the activity of ALDH2 and improve alcohol metabolism in individuals with the variant. However, further research is still needed in this area.

What are the health risks associated with the ALDH2 protein variant? 08/09/2017

The ALDH2*2 variant is associated with an increased risk of alcohol-related health issues. When individuals with the variant consume alcohol, acetaldehyde builds up in their system, causing symptoms such as facial flushing, rapid heartbeat, nausea, and headache. Prolonged alcohol consumption despite these symptoms can lead to an increased risk of various conditions, including esophageal cancer, liver disease, and cardiovascular diseases.

Are there any known benefits of the ALDH2 protein variant? 06/20/2017

While the ALDH2*2 variant is associated with increased susceptibility to alcohol-related symptoms and health risks, it has been found to provide protection against alcohol dependence. The discomfort caused by acetaldehyde accumulation may discourage heavy alcohol consumption, reducing the risk of alcohol addiction.

Is the ALDH2 protein variant common? 10/07/2016

The ALDH2*2 variant is more common in certain populations. It is found at a high frequency in East Asian populations, where an estimated 30-50% of individuals carry at least one copy of the variant. In other populations, the prevalence of the ALDH2*2 variant is generally low.

Customer Reviews (4)

Write a review
Reviews
10/03/2021

    I highly recommend the ALDH2 Protein to researchers seeking a reliable and high-performing protein for their ELISA assays and protein electron microscopy structure analysis.

    01/27/2019

      The ALDH2 Protein has greatly contributed to the success of my experiments, providing reliable and robust data.

      06/29/2018

        Its ability to maintain structural integrity and stability ensures accurate imaging, enabling me to gain deeper insights into the three-dimensional organization and interactions of the proteins under investigation.

        05/13/2018

          Its outstanding performance, coupled with its ease of use, has enhanced the overall efficiency and accuracy of my research.

          Ask a Question for All ALDH2 Products

          Required fields are marked with *

          My Review for All ALDH2 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends