Recombinant Human ALDH4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ALDH4A1-2033H
• Product Overview: ALDH4A1 MS Standard C13 and N15-labeled recombinant protein (NP_003739) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 61.7 kDa
• AA Sequence: MLLPAPALRRALLSRPWTGAGLRWK HTSSLKVANEPVLAFTQGSPERDAL QKALKDLKGRMEAIPCVVGDEEVWT SDVQYQVSPFNHGHKVAKFCYADKS LLNKAIEAALAARKEWDLKPIADRA QIFLKAADMLSGPRRAEILAKTMVG QGKTVIQAEIDAAAELIDFFRFNAK YAVELEGQQPISVPPSTNSTVYRGL EGFVAAISPFNFTAIGGNLAGAPAL MGNVVLWKPSDTAMLASYAVYRILR EAGLPPNIIQFVPADGPLFGDTVTS SEHLCGINFTGSVPTFKHLWKQVAQ NLDRFHTFPRLAGECGGKNFHFVHR SADVESVVSGTLRSAFEYGGQKCSA CSRLYVPHSLWPQIKGRLLEEHSRI KVGDPAEDFGTFFSAVIDAKSFARI KKWLEHARSSPSLTILAGGKCDDSV GYFVEPCIVESKDPQEPIMKEEIFG PVLSVYVYPDDKYKETLQLVDSTTS YGLTGAVFSQDKDVVQEATKVLRNA AGNFYINDKSTGSIVGQQPFGGARA SGTNDKPGGPHYILRWTSPQVIKET HKPLGDWSYAYMQSGPTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ALDH4A1 aldehyde dehydrogenase 4 family member A1 [ Homo sapiens (human) ]
• Official Symbol: ALDH4A1
• Synonyms: ALDH4A1; aldehyde dehydrogenase 4 family, member A1; ALDH4; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5CDh; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5CD; DKFZp779M035
• Gene ID: 8659
• mRNA Refseq: NM_003748
• Protein Refseq: NP_003739
• MIM: 606811
• UniProt ID: P30038