Recombinant Human ALX3 protein, GST-tagged
Cat.No. : | ALX3-510H |
Product Overview : | Human ALX3 partial ORF ( NP_006483, 150 a.a. - 249 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | KSKKRRNRTTFSTFQLEELEKVFQK THYPDVYAREQLALRTDLTEARVQV WFQNRRAKWRKRERYGKIQEGRNPF TAAYDISVLPRTDSHPQLQNSLWAG |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ALX3 ALX homeobox 3 [ Homo sapiens ] |
Official Symbol : | ALX3 |
Synonyms : | ALX3; ALX homeobox 3; aristaless like homeobox 3; homeobox protein aristaless-like 3; aristaless-like homeobox 3; proline-rich transcription factor ALX3; FND1; MGC138212; MGC141988; |
Gene ID : | 257 |
mRNA Refseq : | NM_006492 |
Protein Refseq : | NP_006483 |
MIM : | 606014 |
UniProt ID : | O95076 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALX3 expression is regulated spatially and temporally during embryonic development, with specific patterns in tissues such as the neural tube, limb buds, or craniofacial structures.
Pharmacological or genetic modulation of ALX3 activity may have therapeutic implications for developmental disorders or regenerative medicine, but further studies are needed to explore these possibilities.
ALX3 recognizes specific DNA binding motifs, such as homeobox motifs, and binds to regulatory regions of target genes to regulate their transcriptional activity.
ALX3 forms transcriptional complexes with other transcription factors and co-regulators, such as PAX6 or DLX5, to coordinate gene expression programs essential for embryonic development and tissue morphogenesis.
ALX3 binding sites are associated with specific epigenetic modifications, such as DNA methylation or histone modifications, which contribute to the regulation of ALX3-mediated transcriptional activity.
ALX3 interacts with co-regulatory proteins and other transcription factors, forming complexes that modulate gene expression and cellular processes critical for embryonic development.
ALX3 regulates the expression of genes involved in cell fate determination, tissue patterning, and morphogenesis during embryogenesis, including those encoding transcription factors, extracellular matrix components, or signaling molecules.
ALX3 integrates with signaling pathways, including Wnt, BMP, or FGF signaling, to modulate gene expression and influence cellular behaviors during embryogenesis.
ALX3 regulates cell proliferation, differentiation, and migration during embryogenesis through various molecular mechanisms, including interactions with cell cycle regulators, morphogen gradients, or cytoskeletal components.
Gain-of-function or loss-of-function mutations in ALX3 can disrupt normal embryonic development, leading to craniofacial malformations, limb abnormalities, or neural tube defects.
Customer Reviews (3)
Write a reviewAccurate measurement of protein-protein complex stoichiometry.
Compatible with high-content imaging platforms.
Reduced assay variability for reliable data interpretation.
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