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Recombinant Human ALX3 protein, GST-tagged

Cat.No. : ALX3-510H
Product Overview : Human ALX3 partial ORF ( NP_006483, 150 a.a. - 249 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : KSKKRRNRTTFSTFQLEELEKVFQK THYPDVYAREQLALRTDLTEARVQV WFQNRRAKWRKRERYGKIQEGRNPF TAAYDISVLPRTDSHPQLQNSLWAG
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ALX3 ALX homeobox 3 [ Homo sapiens ]
Official Symbol : ALX3
Synonyms : ALX3; ALX homeobox 3; aristaless like homeobox 3; homeobox protein aristaless-like 3; aristaless-like homeobox 3; proline-rich transcription factor ALX3; FND1; MGC138212; MGC141988;
Gene ID : 257
mRNA Refseq : NM_006492
Protein Refseq : NP_006483
MIM : 606014
UniProt ID : O95076

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is ALX3 expression regulated during embryonic development, particularly in tissues where it plays a critical role? 12/02/2022

ALX3 expression is regulated spatially and temporally during embryonic development, with specific patterns in tissues such as the neural tube, limb buds, or craniofacial structures.

Can ALX3 be targeted pharmacologically or genetically to modulate its activity, and what are the potential therapeutic implications? 11/16/2020

Pharmacological or genetic modulation of ALX3 activity may have therapeutic implications for developmental disorders or regenerative medicine, but further studies are needed to explore these possibilities.

What are the DNA binding motifs recognized by ALX3, and how do they contribute to its transcriptional regulatory activity? 11/08/2020

ALX3 recognizes specific DNA binding motifs, such as homeobox motifs, and binds to regulatory regions of target genes to regulate their transcriptional activity.

How does ALX3 interact with other transcription factors and co-regulators to form transcriptional complexes that control gene expression and cellular fate during embryonic development? 03/15/2020

ALX3 forms transcriptional complexes with other transcription factors and co-regulators, such as PAX6 or DLX5, to coordinate gene expression programs essential for embryonic development and tissue morphogenesis.

What are the epigenetic modifications associated with ALX3 binding sites and how do they modulate ALX3-mediated transcriptional regulation? 12/26/2019

ALX3 binding sites are associated with specific epigenetic modifications, such as DNA methylation or histone modifications, which contribute to the regulation of ALX3-mediated transcriptional activity.

What are the protein-protein interactions of ALX3 and how do these interactions contribute to its function? 12/13/2018

ALX3 interacts with co-regulatory proteins and other transcription factors, forming complexes that modulate gene expression and cellular processes critical for embryonic development.

What are the downstream targets of ALX3, and how does it regulate gene expression to influence cellular processes during embryogenesis? 04/28/2018

ALX3 regulates the expression of genes involved in cell fate determination, tissue patterning, and morphogenesis during embryogenesis, including those encoding transcription factors, extracellular matrix components, or signaling molecules.

How does ALX3 interact with signaling pathways involved in tissue development, such as Wnt, BMP, or FGF signaling? 01/10/2018

ALX3 integrates with signaling pathways, including Wnt, BMP, or FGF signaling, to modulate gene expression and influence cellular behaviors during embryogenesis.

How does ALX3 regulate cell proliferation, differentiation, and migration during embryogenesis, and what are the underlying molecular mechanisms? 07/22/2017

ALX3 regulates cell proliferation, differentiation, and migration during embryogenesis through various molecular mechanisms, including interactions with cell cycle regulators, morphogen gradients, or cytoskeletal components.

What are the effects of ALX3 gain-of-function or loss-of-function mutations on embryonic development, and how do they affect cellular behaviors and tissue morphogenesis? 03/06/2017

Gain-of-function or loss-of-function mutations in ALX3 can disrupt normal embryonic development, leading to craniofacial malformations, limb abnormalities, or neural tube defects.

Customer Reviews (3)

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Reviews
04/20/2020

    Accurate measurement of protein-protein complex stoichiometry.

    12/31/2019

      Compatible with high-content imaging platforms.

      11/16/2017

        Reduced assay variability for reliable data interpretation.

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