Recombinant Human ALX3 protein, GST-tagged
Cat.No. : | ALX3-511H |
Product Overview : | Recombinant Human ALX3 protein(NP_006483)(1-152 aa), fused to GST tag, was expressed in E. coli. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectants before lyophilization. |
Protein length : | 1-152 aa |
AA Sequence : | MDPEHCAPFRVGPAPGPYVASGDEP PGPQGTPAAAPHLHPAPPRGPRLTR FPACGPLEPYLPEPAKPPAKYLQDL GPGPALNGGHFYEGPAEAEEKTSKA ASFPQLPLDCRGGPRDGPSNLQGSP GPCLASLHLPLSPGLPDSMELAKNK SK |
Purity : | 90%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage (see Stability and Storage for more details). If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used). Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. |
Gene Name : | ALX3 ALX homeobox 3 [ Homo sapiens ] |
Official Symbol : | ALX3 |
Synonyms : | ALX3; ALX homeobox 3; aristaless like homeobox 3; homeobox protein aristaless-like 3; aristaless-like homeobox 3; proline-rich transcription factor ALX3; FND1; MGC138212; MGC141988; |
Gene ID : | 257 |
mRNA Refseq : | NM_006492 |
Protein Refseq : | NP_006483 |
MIM : | 606014 |
UniProt ID : | O95076 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALX3 expression is regulated spatially and temporally during embryonic development, with specific patterns in tissues such as the neural tube, limb buds, or craniofacial structures.
Pharmacological or genetic modulation of ALX3 activity may have therapeutic implications for developmental disorders or regenerative medicine, but further studies are needed to explore these possibilities.
ALX3 recognizes specific DNA binding motifs, such as homeobox motifs, and binds to regulatory regions of target genes to regulate their transcriptional activity.
ALX3 forms transcriptional complexes with other transcription factors and co-regulators, such as PAX6 or DLX5, to coordinate gene expression programs essential for embryonic development and tissue morphogenesis.
ALX3 binding sites are associated with specific epigenetic modifications, such as DNA methylation or histone modifications, which contribute to the regulation of ALX3-mediated transcriptional activity.
ALX3 interacts with co-regulatory proteins and other transcription factors, forming complexes that modulate gene expression and cellular processes critical for embryonic development.
ALX3 regulates the expression of genes involved in cell fate determination, tissue patterning, and morphogenesis during embryogenesis, including those encoding transcription factors, extracellular matrix components, or signaling molecules.
ALX3 integrates with signaling pathways, including Wnt, BMP, or FGF signaling, to modulate gene expression and influence cellular behaviors during embryogenesis.
ALX3 regulates cell proliferation, differentiation, and migration during embryogenesis through various molecular mechanisms, including interactions with cell cycle regulators, morphogen gradients, or cytoskeletal components.
Gain-of-function or loss-of-function mutations in ALX3 can disrupt normal embryonic development, leading to craniofacial malformations, limb abnormalities, or neural tube defects.
Customer Reviews (3)
Write a reviewAccurate measurement of protein-protein complex stoichiometry.
Compatible with high-content imaging platforms.
Reduced assay variability for reliable data interpretation.
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