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Recombinant Human ALX3 protein, GST-tagged

Cat.No. : ALX3-511H
Product Overview : Recombinant Human ALX3 protein(NP_006483)(1-152 aa), fused to GST tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : GST
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectants before lyophilization.
Protein length : 1-152 aa
AA Sequence : MDPEHCAPFRVGPAPGPYVASGDEP PGPQGTPAAAPHLHPAPPRGPRLTR FPACGPLEPYLPEPAKPPAKYLQDL GPGPALNGGHFYEGPAEAEEKTSKA ASFPQLPLDCRGGPRDGPSNLQGSP GPCLASLHLPLSPGLPDSMELAKNK SK
Purity : 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Short-term storage: Store at 2-8°C for (1-2 weeks).
Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage (see Stability and Storage for more details).
If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used).
Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution.
Gene Name : ALX3 ALX homeobox 3 [ Homo sapiens ]
Official Symbol : ALX3
Synonyms : ALX3; ALX homeobox 3; aristaless like homeobox 3; homeobox protein aristaless-like 3; aristaless-like homeobox 3; proline-rich transcription factor ALX3; FND1; MGC138212; MGC141988;
Gene ID : 257
mRNA Refseq : NM_006492
Protein Refseq : NP_006483
MIM : 606014
UniProt ID : O95076

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is ALX3 expression regulated during embryonic development, particularly in tissues where it plays a critical role? 12/02/2022

ALX3 expression is regulated spatially and temporally during embryonic development, with specific patterns in tissues such as the neural tube, limb buds, or craniofacial structures.

Can ALX3 be targeted pharmacologically or genetically to modulate its activity, and what are the potential therapeutic implications? 11/16/2020

Pharmacological or genetic modulation of ALX3 activity may have therapeutic implications for developmental disorders or regenerative medicine, but further studies are needed to explore these possibilities.

What are the DNA binding motifs recognized by ALX3, and how do they contribute to its transcriptional regulatory activity? 11/08/2020

ALX3 recognizes specific DNA binding motifs, such as homeobox motifs, and binds to regulatory regions of target genes to regulate their transcriptional activity.

How does ALX3 interact with other transcription factors and co-regulators to form transcriptional complexes that control gene expression and cellular fate during embryonic development? 03/15/2020

ALX3 forms transcriptional complexes with other transcription factors and co-regulators, such as PAX6 or DLX5, to coordinate gene expression programs essential for embryonic development and tissue morphogenesis.

What are the epigenetic modifications associated with ALX3 binding sites and how do they modulate ALX3-mediated transcriptional regulation? 12/26/2019

ALX3 binding sites are associated with specific epigenetic modifications, such as DNA methylation or histone modifications, which contribute to the regulation of ALX3-mediated transcriptional activity.

What are the protein-protein interactions of ALX3 and how do these interactions contribute to its function? 12/13/2018

ALX3 interacts with co-regulatory proteins and other transcription factors, forming complexes that modulate gene expression and cellular processes critical for embryonic development.

What are the downstream targets of ALX3, and how does it regulate gene expression to influence cellular processes during embryogenesis? 04/28/2018

ALX3 regulates the expression of genes involved in cell fate determination, tissue patterning, and morphogenesis during embryogenesis, including those encoding transcription factors, extracellular matrix components, or signaling molecules.

How does ALX3 interact with signaling pathways involved in tissue development, such as Wnt, BMP, or FGF signaling? 01/10/2018

ALX3 integrates with signaling pathways, including Wnt, BMP, or FGF signaling, to modulate gene expression and influence cellular behaviors during embryogenesis.

How does ALX3 regulate cell proliferation, differentiation, and migration during embryogenesis, and what are the underlying molecular mechanisms? 07/22/2017

ALX3 regulates cell proliferation, differentiation, and migration during embryogenesis through various molecular mechanisms, including interactions with cell cycle regulators, morphogen gradients, or cytoskeletal components.

What are the effects of ALX3 gain-of-function or loss-of-function mutations on embryonic development, and how do they affect cellular behaviors and tissue morphogenesis? 03/06/2017

Gain-of-function or loss-of-function mutations in ALX3 can disrupt normal embryonic development, leading to craniofacial malformations, limb abnormalities, or neural tube defects.

Customer Reviews (3)

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Reviews
04/20/2020

    Accurate measurement of protein-protein complex stoichiometry.

    12/31/2019

      Compatible with high-content imaging platforms.

      11/16/2017

        Reduced assay variability for reliable data interpretation.

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