Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human AP4S1 Protein, His-tagged

Cat.No. : AP4S1-328H
Product Overview : Recombinant Human AP4S1, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
Source : E. coli
Tag : His
Form : 50mM Tris, 8M Urea, pH8.0.
Molecular Mass : 18.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : AP4S1 adaptor-related protein complex 4, sigma 1 subunit [ Homo sapiens ]
Official Symbol : AP4S1
Synonyms : AP47B; CLA20; CPSQ6; SPG52; CLAPS4; AP4S1;
Gene ID : 11154
mRNA Refseq : NM_001128126.2
Protein Refseq : NP_001121598.1
MIM : 607243
UniProt ID : Q9Y587

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (17)

Ask a question
Is AP4S1 mutation associated with infantile spasms? 03/27/2022

Yes, in some patients with infantile spasms, there is a mutation in the AP4S1 gene, suggesting that the AP4S1 gene mutation may be associated with the onset of infantile spasms.

Are there specific targeted drugs associated with AP4S1? 02/28/2022

There are currently no specific targeted drugs for AP4S1, but new therapeutical targets may emerge in the future.

What is the association between recombinant AP4S1 and certain diseases? 02/23/2022

I am not aware of the association between AP4S1 and any specific disease, please provide more specific information.

Is AP4S1 involved in synaptic damage and regeneration? 02/21/2022

Yes, the AP4S1 protein is involved in regulating synaptic formation and damage repair, and may promote the occurrence of nerve regeneration.

Which genes are affected by AP4S1 mutations? 02/01/2022

Mutations in the AP4S1 gene may affect the expression and regulation of a variety of genes, including those involved in neuronal development, synaptic formation, and neurotransmitter transport.

What is the action mechanism of AP4S1 ? 12/08/2021

The exact mechanism of action of AP4S1 needs to be determined by further scientific research and experiments.

In what neurological diseases is AP4S1 found? 09/30/2021

AP4S1 is mutated in a variety of neurological disorders, including Hereditary Spastic Paraplegia, motor neurone disease, autism, psychiatric disorders, infantile spasms, and more.

Is AP4S1 gene involved in the occurrence of mental disorders? 04/17/2021

In some mental disorders, there is a mutation in the AP4S1 gene, indicating that AP4S1 may be involved in the occurrence of mental disorders.

What is the significance of the study of AP4S1 ? 01/31/2021

The study of AP4S1 may help to further understand the mechanism of related diseases and provide clues for potential treatments.

What is the role of AP4S1 protein in the adult nervous system? 11/27/2020

The role of AP4S1 protein in the adult nervous system includes synaptic plasticity, neurotransmitter transport and regulation.

What are the side effects of AP4S1 on human body? 11/23/2020

For the side effects of AP4S1 , it is necessary to analyze and study its role and influence in human body to have a clear answer.

Does the study of AP4S1 involve animal experiments? 08/04/2020

The study of AP4S1 may involve animal experiments, but the specific situation needs to refer to relevant research papers and experimental design.

What are the structural characteristics of AP4S1 ? 05/31/2020

For the structural characteristics of AP4S1 , you can refer to the relevant scientific literature or protein database for detailed information.

How does AP4S1 regulate synaptic enhancement and inhibition in neurons? 09/06/2019

The AP4S1 protein regulates amino acid transport and neurotransmitter release at the synapses of neurons, thereby affecting the occurrence of synaptic enhancement and inhibition.

How is the research progress of AP4S1 ? 04/12/2019

For the latest research progress of AP4S1 , you can get more detailed information from the relevant scientific literature.

How to treat AP4S1-related diseases? 02/14/2019

Due to the wide variety of AP4S1-related diseases, the treatment methods are not the same, which can be treated by drug therapy, gene therapy and other ways. Specific treatments for the AP4S1 gene are still being studied.

What is the synthesis method of AP4S1 ? 02/01/2019

The specific synthesis method is not clear to me, but in general, the synthesis of s can be achieved through genetic engineering technology.

Customer Reviews (4)

Write a review
Reviews
10/17/2022

    Reproducibility of AP4S1 is so good that the results are highly consistent regardless of the conditions under which the experiment or application is carried out, greatly reducing experimental errors.

    04/24/2020

      AP4S1 produced by them has strong activity and obvious experimental effect.

      10/15/2019

        Catalytic activity of AP4S1 is very powerful, even in the face of complex chemical reactions can also be easily adapted, and its ability to adapt is amazing.

        01/08/2019

          Repeatability of AP4S1 is very good, and the results of each experiment are very consistent, indicating that its production process is very careful.

          Ask a Question for All AP4S1 Products

          Required fields are marked with *

          My Review for All AP4S1 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends