Recombinant Human AP4S1 Protein, His-tagged
Cat.No. : | AP4S1-328H |
Product Overview : | Recombinant Human AP4S1, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. |
Source : | E. coli |
Tag : | His |
Form : | 50mM Tris, 8M Urea, pH8.0. |
Molecular Mass : | 18.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | AP4S1 adaptor-related protein complex 4, sigma 1 subunit [ Homo sapiens ] |
Official Symbol : | AP4S1 |
Synonyms : | AP47B; CLA20; CPSQ6; SPG52; CLAPS4; AP4S1; |
Gene ID : | 11154 |
mRNA Refseq : | NM_001128126.2 |
Protein Refseq : | NP_001121598.1 |
MIM : | 607243 |
UniProt ID : | Q9Y587 |
Products Types
◆ Recombinant Protein | ||
AP4S1-610M | Recombinant Mouse AP4S1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AP4S1-1120Z | Recombinant Zebrafish AP4S1 | +Inquiry |
AP4S1-1753M | Recombinant Mouse AP4S1 Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (17)
Ask a questionYes, in some patients with infantile spasms, there is a mutation in the AP4S1 gene, suggesting that the AP4S1 gene mutation may be associated with the onset of infantile spasms.
There are currently no specific targeted drugs for AP4S1, but new therapeutical targets may emerge in the future.
I am not aware of the association between AP4S1 and any specific disease, please provide more specific information.
Yes, the AP4S1 protein is involved in regulating synaptic formation and damage repair, and may promote the occurrence of nerve regeneration.
Mutations in the AP4S1 gene may affect the expression and regulation of a variety of genes, including those involved in neuronal development, synaptic formation, and neurotransmitter transport.
The exact mechanism of action of AP4S1 needs to be determined by further scientific research and experiments.
AP4S1 is mutated in a variety of neurological disorders, including Hereditary Spastic Paraplegia, motor neurone disease, autism, psychiatric disorders, infantile spasms, and more.
In some mental disorders, there is a mutation in the AP4S1 gene, indicating that AP4S1 may be involved in the occurrence of mental disorders.
The study of AP4S1 may help to further understand the mechanism of related diseases and provide clues for potential treatments.
The role of AP4S1 protein in the adult nervous system includes synaptic plasticity, neurotransmitter transport and regulation.
For the side effects of AP4S1 , it is necessary to analyze and study its role and influence in human body to have a clear answer.
The study of AP4S1 may involve animal experiments, but the specific situation needs to refer to relevant research papers and experimental design.
For the structural characteristics of AP4S1 , you can refer to the relevant scientific literature or protein database for detailed information.
The AP4S1 protein regulates amino acid transport and neurotransmitter release at the synapses of neurons, thereby affecting the occurrence of synaptic enhancement and inhibition.
For the latest research progress of AP4S1 , you can get more detailed information from the relevant scientific literature.
Due to the wide variety of AP4S1-related diseases, the treatment methods are not the same, which can be treated by drug therapy, gene therapy and other ways. Specific treatments for the AP4S1 gene are still being studied.
The specific synthesis method is not clear to me, but in general, the synthesis of s can be achieved through genetic engineering technology.
Customer Reviews (4)
Write a reviewReproducibility of AP4S1 is so good that the results are highly consistent regardless of the conditions under which the experiment or application is carried out, greatly reducing experimental errors.
AP4S1 produced by them has strong activity and obvious experimental effect.
Catalytic activity of AP4S1 is very powerful, even in the face of complex chemical reactions can also be easily adapted, and its ability to adapt is amazing.
Repeatability of AP4S1 is very good, and the results of each experiment are very consistent, indicating that its production process is very careful.
Ask a Question for All AP4S1 Products
Required fields are marked with *
My Review for All AP4S1 Products
Required fields are marked with *
Inquiry Basket