Recombinant Human APH1A Protein (1-247 aa), His-SUMO-tagged

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Recombinant Human APH1A Protein (1-247 aa), His-SUMO-tagged

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Cat.No. : APH1A-2712H
Product Overview : Recombinant Human APH1A Protein (1-247 aa) is produced by in vitro E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Partial.
Description : Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Source : E. coli Cell Free
Species : Human
Tag : His-SUMO
Form : Tris-based buffer,50% glycerol
Molecular Mass : 42.9 kDa
Protein length : 1-247 aa
AA Sequence : MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ RSLLCRR
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : APH1A anterior pharynx defective 1 homolog A (C. elegans) [ Homo sapiens ]
Official Symbol : APH1A
Synonyms : APH1A; APH 1A; CGI 78; aph-1alpha; presenilin-stabilization factor; APH-1; APH-1A; CGI-78; 6530402N02Rik;
Gene ID : 51107
mRNA Refseq : NM_001077628
Protein Refseq : NP_001071096
MIM : 607629
UniProt ID : Q96BI3

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