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Recombinant Human APOL1 Protein, MYC/DDK-tagged

Cat.No. : APOL1-2472H
Product Overview : Recombinant Human APOL1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 41.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : APOL1 apolipoprotein L, 1 [ Homo sapiens ]
Official Symbol : APOL1
Synonyms : APO-L; APOL; APOL-I; FSGS4
Gene ID : 8542
mRNA Refseq : NM_001136540
Protein Refseq : NP_001130012
MIM : 603743
UniProt ID : O14791

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Can lifestyle modifications help reduce the risk or slow the progression of APOL1-associated kidney diseases? 01/22/2023

While genetic factors play a significant role in APOL1-associated kidney diseases, lifestyle modifications can still be beneficial in reducing the risk or slowing the progression of these conditions. Adhering to a healthy diet, maintaining a healthy weight, exercising regularly, managing blood pressure, and avoiding smoking can all have a positive impact on kidney health. These lifestyle adjustments, in combination with medical treatments, can help to mitigate the effects of APOL1 genetic variants on kidney function.

How does APOL1 testing impact kidney transplant outcomes? 11/12/2022

APOL1 genetic testing is becoming increasingly relevant in the field of kidney transplantation. Individuals with APOL1 risk variants who receive a kidney transplant from a living or deceased donor with the same risk variants may be at higher risk for kidney complications and graft failure. Therefore, APOL1 testing can help inform decisions regarding donor selection and overall transplant management, potentially leading to improved outcomes for transplant recipients with these genetic variants.

Are there any known population-specific differences in APOL1 genetic variants? 03/21/2022

Yes, there are variations in the prevalence of APOL1 genetic variants among different populations. The G1 and G2 variants are more common in individuals of African ancestry, particularly those from sub-Saharan Africa. These variants are believed to have evolved as a protective mechanism against the parasite Trypanosoma brucei, which causes sleeping sickness. However, the same variants that provide protection against the parasite can also increase the risk of kidney diseases.

Are there any potential treatment breakthroughs or promising research findings related to APOL1-associated kidney diseases? 11/25/2021

There has been significant research interest in APOL1-associated kidney diseases in recent years, and several promising findings have emerged. Some studies have identified novel therapeutic targets, such as inflammatory pathways and cellular processes, that could potentially be targeted for treatment development. Additionally, researchers are investigating the use of gene editing techniques, such as CRISPR-Cas9, to modify or remove the high-risk APOL1 genetic variants to potentially prevent or treat APOL1-associated kidney diseases. However, it is important to note that these breakthroughs and findings are still in the experimental stages and require further investigation before they can be applied clinically.

How common are APOL1 genetic variants in the general population? 10/01/2021

APOL1 genetic variants are more prevalent in individuals of African descent. Approximately 12-15% of individuals with African ancestry carry two copies (homozygotes) of the high-risk APOL1 genetic variants. However, it's important to note that not all individuals with these genetic variants will develop APOL1-associated kidney diseases. Other factors like environmental triggers and genetic modifiers may also play a role in the development and progression of these conditions.

What resources are available for people seeking more information about APOL1-associated kidney diseases? 02/05/2021

There are several resources available for individuals seeking more information about APOL1-associated kidney diseases. Organizations such as the National Kidney Foundation, the American Society of Nephrology, and the American Association of Kidney Patients provide educational materials, support groups, and guidance for patients and caregivers. Genetic counseling services can also be valuable in understanding the implications of APOL1 genetic variants and making informed decisions about genetic testing and healthcare management.

Are there any other roles of APOL1 protein? 02/02/2021

Besides its function in fighting trypanosome infections, APOL1 has been implicated in other cellular processes. It has been associated with kidney function and has been linked to the risk of developing various kidney diseases, including focal segmental glomerulosclerosis (FSGS) and hypertension-associated nephropathy.

Are there any patient advocacy groups specifically focused on APOL1-associated kidney diseases? 01/17/2021

Yes, there are patient advocacy groups that specifically focus on APOL1-associated kidney diseases. For example, the APOL1 Kidney Foundation is dedicated to raising awareness, providing support, and promoting research for individuals affected by APOL1-related kidney diseases. They offer educational resources, support groups, and fundraising initiatives to support research efforts. Connecting with patient advocacy groups can provide a network of support and up-to-date information for individuals and families dealing with APOL1-associated kidney diseases.

Can APOL1 genetic testing be useful in clinical practice? 12/08/2020

APOL1 genetic testing can provide valuable information in certain clinical scenarios. For individuals with African ancestry who have been diagnosed with kidney diseases or are at a higher risk based on their family history, genetic testing for APOL1 variants may help determine the underlying cause of the disease or provide additional risk assessment. However, the use of APOL1 genetic testing in clinical practice is still evolving, and its utility and interpretation should be discussed with a healthcare professional or genetic counselor.

Is there any treatment available for APOL1-associated kidney diseases? 01/20/2020

Currently, there is no specific treatment targeting APOL1-associated kidney diseases. Treatment usually focuses on managing symptoms and slowing the progression of the disease. However, ongoing research aims to better understand the underlying mechanisms and develop potential targeted therapies in the future.

How do genetic variants of APOL1 contribute to the risk of kidney diseases? 07/30/2019

Research has found that certain genetic variants of APOL1, particularly G1 and G2 variants, increase the risk of developing kidney diseases. These variants have been found to be more common in people of African ancestry. The exact mechanisms through which these variants contribute to kidney disease risk are still being investigated, but it is believed that the variants may impair the normal functioning of APOL1 in kidney cells, leading to kidney damage and an increased susceptibility to diseases such as FSGS and hypertension-associated nephropathy.

Can APOL1 genetic testing be done at home or does it require a healthcare provider? 04/17/2019

APOL1 genetic testing typically requires a healthcare provider. Genetic testing for APOL1 variants is typically performed through clinical laboratories that specialize in genetic testing. A healthcare provider, such as a nephrologist or a genetic counselor, can order the test, explain its significance, and interpret the results. It's important to have a healthcare professional's guidance to understand the implications of APOL1 genetic variants and make informed decisions regarding healthcare management.

Are there any ongoing clinical trials focused on APOL1-associated kidney diseases? 07/08/2018

Yes, there are ongoing clinical trials investigating APOL1-associated kidney diseases. Some trials are examining the effects of different treatments on kidney function in individuals with APOL1 genetic variants who have kidney diseases such as focal segmental glomerulosclerosis (FSGS) and hypertension-associated nephropathy. These trials aim to evaluate the effectiveness of various interventions, such as medications and lifestyle modifications, in slowing the progression of kidney diseases or preventing complications.

Are there any potential targeted therapies being developed for APOL1-associated kidney diseases? 06/17/2018

The identification of specific molecular pathways related to APOL1-associated kidney diseases has opened up possibilities for targeted therapeutic interventions. Researchers are exploring strategies to modulate the expression or function of APOL1 in kidney cells to prevent or ameliorate the damage caused by APOL1 genetic variants. Additionally, studies are investigating the role of other proteins and cellular mechanisms that interact with APOL1, with the goal of developing targeted therapies that can specifically address the underlying disease processes in APOL1-associated kidney diseases.

Can APOL1 genetic variants be tested for? 02/06/2018

Yes, APOL1 genetic variants can be determined through genetic testing. However, it is important to note that the presence of these variants does not necessarily mean an individual will develop kidney disease. It is recommended to consult with a healthcare professional or genetic counselor for more information and interpretation of genetic test results.

How is APOL1 associated with kidney diseases? 10/30/2017

Certain genetic variants of APOL1 are more commonly found in individuals of African ancestry and are associated with an increased risk of developing kidney diseases. These variants of APOL1 may cause kidney damage by unknown mechanisms, leading to a higher susceptibility to kidney diseases.

Are there any other health conditions associated with APOL1 genetic variants? 04/28/2017

In addition to kidney diseases, APOL1 genetic variants have also been linked to other health conditions. Some studies have suggested an association between APOL1 variants and an increased risk of cardiovascular diseases, such as heart disease and stroke. However, further research is needed to fully understand the extent of this association.

What are the current treatment options for APOL1-associated kidney diseases? 06/11/2016

The treatment options for APOL1-associated kidney diseases depend on the specific condition and its progression. Generally, the management of APOL1-associated kidney diseases involves a combination of pharmacological interventions, lifestyle modifications, and monitoring. Medications such as angiotensin-converting enzyme inhibitors (ACE inhibitors) or angiotensin receptor blockers (ARBs) may be prescribed to help control blood pressure and reduce proteinuria. Dietary changes, including reducing sodium intake and restricting protein consumption, may also be recommended. In more severe cases, dialysis or kidney transplantation may be necessary.

Customer Reviews (4)

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Reviews
07/17/2022

    One of the key advantages of using APOL1 protein in trials is its high quality.

    01/17/2020

      They ensure a consistent and reliable supply of APOL1 protein, minimizing any potential disruptions in my experimental workflow.

      06/17/2019

        Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.

        08/18/2018

          This collaborative approach empowers me to integrate cutting-edge knowledge, explore innovative techniques, and expand the impact of my research.

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