Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ARL10C protein, GST-tagged

Cat.No. : ARL10C-803H
Product Overview : Human ARL10C full-length ORF ( AAH13131, 1 a.a. - 186 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : ARL8B (ADP Ribosylation Factor Like GTPase 8B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8A.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 46.2 kDa
AA Sequence : MLALISRLLDWFRSLFWKEEMELTL VGLQYSGKTTFVNVIASGQFSEDMI PTVGFNMRKVTKGNVTIKIWDIGGQ PRFRSMWERYCRGVNAIVYMIDAAD REKIEASRNELHNLLDKPQLQGIPV LVLGNKRDLPNALDEKQLIEKMNLS AIQDREICCYSISCKEKDNIDITLQ WLIQHSKSRRS
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARL8B ADP-ribosylation factor-like 8B [ Homo sapiens ]
Official Symbol : ARL8B
Synonyms : ARL8B; ADP-ribosylation factor-like 8B; ADP ribosylation factor like 10C , ARL10C; ADP-ribosylation factor-like protein 8B; FLJ10702; Gie1; ADP-ribosylation factor-like 10C; ADP-ribosylation factor-like protein 10C; novel small G protein indispensable for equal chromosome segregation 1; ARL10C;
Gene ID : 55207
mRNA Refseq : NM_018184
Protein Refseq : NP_060654
UniProt ID : Q9NVJ2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (16)

Ask a question
Can ARL8B affect cellular metabolism? 04/06/2023

There are indications that ARL8B can influence cellular metabolism. It has been shown to regulate autophagy, a process involved in cellular recycling and metabolism. Modulation of ARL8B activity may impact metabolic processes, although further research is needed to fully understand its role in cellular metabolism.

Does ARL8B have any specific interacting partners? 05/17/2022

ARL8B interacts with various proteins to carry out its functions. For example, it interacts with SKIP (SifA and kinesin-interacting protein) to regulate lysosomal trafficking and fusion with endocytic compartments.

Does ARL8B play a role in immune response? 07/15/2021

Yes, ARL8B has been implicated in immune response pathways. It influences the trafficking and maturation of immune-related vesicles, such as phagolysosomes, which are involved in the processing of microbial pathogens.

Does ARL8B contribute to neuronal development or function? 05/17/2021

While the specific role of ARL8B in neuronal development or function has not been extensively studied, its involvement in lysosomal trafficking and autophagy suggests it may have implications for neuronal homeostasis and pathology. Further research is needed to explore this connection.

Are there any known post-translational modifications of the ARL8B protein? 04/24/2021

Yes, ARL8B can undergo various post-translational modifications, such as phosphorylation and ubiquitination, which can regulate its activity and interactions with other cellular components.

Can aberrant ARL8B expression contribute to disease development? 02/08/2021

Dysregulation of ARL8B expression or function has been implicated in certain diseases. For example, altered ARL8B expression has been observed in cancer cells and neurodegenerative disorders, suggesting its potential involvement in disease progression.

Does ARL8B have any roles in cellular homeostasis? 01/12/2021

Yes, ARL8B is involved in maintaining cellular homeostasis by regulating processes such as lysosomal function, vesicle trafficking, autophagy, and endocytic recycling. Disruption of ARL8B function can lead to imbalances in these processes, potentially affecting cellular homeostasis.

Are there any known mutations or polymorphisms in the ARL8B gene? 03/02/2020

Limited information is available on mutations or polymorphisms in the ARL8B gene. However, like other genes, variations such as single nucleotide polymorphisms (SNPs) may exist in the population, and their functional significance requires further investigation.

Are there any known ARL8B animal models? 01/30/2020

Yes, there are ARL8B knockout mouse models that have been generated to study its functions in vivo. These models provide valuable insights into the physiological roles of ARL8B and its implications in disease.

Is ARL8B expression tissue-specific? 01/22/2020

ARL8B is expressed in various tissues and cell types. Its expression levels may vary among different tissues, indicating potential tissue-specific regulation or functions.

Can ARL8B play a role in autophagy? 04/28/2019

Yes, ARL8B is involved in autophagy, promoting the fusion of autophagosomes with lysosomes for cargo degradation. It is essential for autophagosome-lysosome fusion and proper autophagic flux.

Does ARL8B have any roles in intracellular vesicle transport? 06/13/2018

Yes, ARL8B plays a crucial role in intracellular vesicle transport. It facilitates the movement of vesicles along microtubules and regulates their fusion with target membranes, ensuring proper cargo delivery and organelle homeostasis.

Are there any drugs or therapeutic interventions targeting ARL8B? 02/06/2018

Currently, there are no specific drugs or therapeutic interventions targeting ARL8B. However, as our understanding of its role in cellular processes and diseases advances, it may become a potential target for future drug development.

Can ARL8B be used as a target for drug delivery or nanomedicine? 12/01/2017

ARL8B's involvement in lysosomal trafficking and autophagy pathways suggests it may have potential as a target for drug delivery or nanomedicine approaches. Modulating ARL8B function could potentially enhance cargo delivery to specific cellular compartments. However, further research is needed to explore this possibility.

Can ARL8B be targeted for therapeutic purposes? 09/13/2017

Targeting ARL8B for therapeutic purposes is an area of ongoing research. Given its involvement in cellular processes relevant to diseases, modulating ARL8B activity or interactions may hold potential for future therapeutic interventions.

Does ARL8B have any implications in neurodegenerative diseases? 05/11/2017

There is emerging evidence linking ARL8B to neurodegenerative diseases such as Parkinson's disease. Altered ARL8B expression or function may disrupt lysosomal trafficking and autophagy, leading to accumulation of protein aggregates and neurotoxicity.

Customer Reviews (8)

Write a review
Reviews
04/15/2023

    The manufacturer also ensures that the ARL8B protein is well-characterized, with extensive documentation on its functional properties.

    06/18/2022

      the ease of use and compatibility of the ARL8B protein with various techniques further enhances its appeal.

      01/26/2022

        It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

        10/16/2021

          With its well-characterized nature and availability in various formats, the arnC protein is an advantageous tool that aids researchers in achieving their scientific goals.

          12/31/2020

            the ARL8B protein is available in different formats, including recombinant and purified variants.

            07/07/2020

              This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

              05/24/2019

                the ARL8B protein stands out for its excellent quality, exceptional technical support, and wide range of applications.

                06/26/2017

                  The ARL8B protein is a top-quality product that is sure to fulfill my experimental requirements.

                  Ask a Question for All ARL8B Products

                  Required fields are marked with *

                  My Review for All ARL8B Products

                  Required fields are marked with *

                  0

                  Inquiry Basket

                  cartIcon
                  logo

                  FOLLOW US

                  Terms and Conditions        Privacy Policy

                  Copyright © 2024 Creative BioMart. All Rights Reserved.

                  Contact Us

                  • /

                  Stay Updated on the Latest Bioscience Trends