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Recombinant Human ASB3 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ASB3-5082H
Product Overview : ASB3 MS Standard C13 and N15-labeled recombinant protein (NP_665862) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 57.7 kDa
AA Sequence : MDFTEAYADTCSTVGLAAREGNVKV LRKLLKKGRSVDVADNRGWMPIHEA AYHNSVECLQMLINADSSENYIKMK TFEGFCALHLAASQGHWKIVQILLE AGADPNATTLEETTPLFLAVENGQI DVLRLLLQHGANVNGSHSMCGWNSL HQASFQENAEIIKLLLRKGANKECQ DDFGITPLFVAAQYGKLESLSILIS SGANVNCQALDKATPLFIAAQEGHT KCVELLLSSGADPDLYCNEDSWQLP IHAAAQMGHTKILDLLIPLTNRACD TGLNKVSPVYSAVFGGHEDCLEILL RNGYSPDAQACLVFGFSSPVCMAFQ KDCEFFGIVNILLKYGAQINELHLA YCLKYEKFSIFRYFLRKGCSLGPWN HIYEFVNHAIKAQAKYKEWLPHLLV AGFDPLILLCNSWIDSVSIDTLIFT LEFTNWKTLAPAVERMLSARASNAW ILQQHIATVPSLTHLCRLEIRSSLK SERLRSDSYISQLPLPRSLHNYLLY EDVLRMYEVPELAAIQDGTRTRPLE QKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ASB3 ankyrin repeat and SOCS box containing 3 [ Homo sapiens (human) ]
Official Symbol : ASB3
Synonyms : ASB3; ankyrin repeat and SOCS box containing 3; ankyrin repeat and SOCS box protein 3; ASB 3; ASB-3;
Gene ID : 51130
mRNA Refseq : NM_145863
Protein Refseq : NP_665862
MIM : 605760
UniProt ID : Q9Y575

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any known interactions of the ASB3 protein with other proteins? 09/20/2022

Yes, ASB3 has been shown to interact with several proteins, including Cullin 5, Elongin BC complex, and the E3 ubiquitin ligase complex, among others.

Does ASB3 have any known substrates for protein degradation? 07/11/2022

ASB3 has been reported to target proteins such as Notch1, Smurf1, and Fanconi anemia-associated protein FANCC for ubiquitination and subsequent degradation.

Is ASB3 involved in any specific cellular pathways or processes? 08/26/2020

ASB3 is involved in regulating various pathways, including the Notch signaling pathway, TGF-β signaling pathway, and Wnt/β-catenin signaling pathway, among others.

Are there any known small molecules or drugs that can modulate ASB3 activity? 03/21/2020

Currently, there are no known small molecules or drugs specifically targeting ASB3 activity, but further research may unveil potential therapeutic interventions.

Are there any genetic variations or polymorphisms in the ASB3 gene? 09/26/2019

Yes, various genetic variations and polymorphisms in the ASB3 gene have been identified, some of which have been associated with certain diseases and conditions.

Can mutations in the ASB3 gene lead to any disorders? 10/01/2018

Mutations in the ASB3 gene have been found in individuals with intellectual disability and developmental delay, suggesting a potential role in these disorders.

Is ASB3 expression regulated by environmental factors? 08/04/2017

The regulation of ASB3 expression by environmental factors is not well-documented. More research is needed to investigate this aspect.

Customer Reviews (3)

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Reviews
12/05/2022

    Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

    10/13/2016

      With the ASB3 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

      06/06/2016

        Its exceptional properties and reliable results make it a valuable tool in various experimental applications.

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