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Recombinant Human ATP6V0A4 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ATP6V0A4-6451H
Product Overview : ATP6V0A4 MS Standard C13 and N15-labeled recombinant protein (NP_065683) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 96.2 kDa
AA Sequence : MVSVFRSEEMCLSQLFLQVEAAYCC VAELGELGLVQFKDLNMNVNSFQRK FVNEVRRCESLERILRFLEDEMQNE IVVQLLEKSPLTPLPREMITLETVL EKLEGELQEANQNQQALKQSFLELT ELKYLLKKTQDFFETETNLADDFFT EDTSGLLELKAVPAYMTGKLGFIAG VINRERMASFERLLWRICRGNVYLK FSEMDAPLEDPVTKEEIQKNIFIIF YQGEQLRQKIKKICDGFRATVYPCP EPAVERREMLESVNVRLEDLITVIT QTESHRQRLLQEAAANWHSWLIKVQ KMKAVYHILNMCNIDVTQQCVIAEI WFPVADATRIKRALEQGMELSGSSM APIMTTVQSKTAPPTFNRTNKFTAG FQNIVDAYGVGSYREINPAPYTIIT FPFLFAVMFGDCGHGTVMLLAALWM ILNERRLLSQKTDNEIWNTFFHGRY LILLMGIFSIYTGLIYNDCFSKSLN IFGSSWSVQPMFRNGTWNTHVMEES LYLQLDPAIPGVYFGNPYPFGIDPI WNLASNKLTFLNSYKMKMSVILGIV QMVFGVILSLFNHIYFRRTLNIILQ FIPEMIFILCLFGYLVFMIIFKWCC FDVHVSQHAPSILIHFINMFLFNYS DSSNAPLYKHQQEVQSFFVVMALIS VPWMLLIKPFILRASHRKSQLQASR IQEDATENIEGDSSSPSSRSGQRTS ADTHGALDDHGEEFNFGDVFVHQAI HTIEYCLGCISNTASYLRLWALSLA HAQLSEVLWTMVMNSGLQTRGWGGI VGVFIIFAVFAVLTVAILLIMEGLS AFLHALRLHWVEFQNKFYVGDGYKF SPFSFKHILDGTAEETRTRPLEQKL ISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ATP6V0A4 ATPase H+ transporting V0 subunit a4 [ Homo sapiens (human) ]
Official Symbol : ATP6V0A4
Synonyms : ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4; ATP6N1B, ATP6N2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1B, ATPase, H+ transporting, lysosomal V0 subunit a isoform 4, ATPase, H+ transporting, lysosomal V0 subunit A4, RTA1C; V-type proton ATPase 116 kDa subunit a isoform 4; a4; RDRTA2; RTADR; Stv1; Vph1; VPP2; V-ATPase 116 kDa; vacuolar proton pump, subunit 2; V-type proton ATPase 116 kDa subunit a; vacuolar proton pump 116 kDa accessory subunit; vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform; H(+)-transporting two-sector ATPase, noncatalytic accessory protein 1B; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD); A4; STV1; VPH1; RTA1C; ATP6N2; ATP6N1B; MGC130016; MGC130017;
Gene ID : 50617
mRNA Refseq : NM_020632
Protein Refseq : NP_065683
MIM : 605239
UniProt ID : Q9HBG4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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