Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ATXN2L Protein, MYC/DDK-tagged

Cat.No. : ATXN2L-3038H
Product Overview : Recombinant Human ATXN2L protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 115.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ATXN2L ataxin 2-like [ Homo sapiens ]
Official Symbol : ATXN2L
Synonyms : A2D; A2LG; A2LP; A2RP
Gene ID : 11273
mRNA Refseq : NM_007245
Protein Refseq : NP_009176
MIM : 607931
UniProt ID : Q8WWM7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do ATXN2L protein abnormalities lead to neurological diseases? 01/26/2022

At present, the relationship between ATXN2L protein and nervous system diseases is not fully understood. However, some studies have shown that the mutation or abnormal expression of ATXN2L protein may lead to the dysfunction of this protein in cells, thereby affecting the normal function of nerve cells.

How is the function of ATXN2L protein regulated? 02/04/2021

The regulation of ATXN2L protein function involves multiple levels. For example, its expression levels can be influenced by transcription factors and RNA splicing regulation. In addition, it interacts with other proteins to form complexes involved in the regulation of cellular processes.

Which diseases or pathological processes are associated with ATXN2L protein? 11/10/2020

Current studies have shown that ATXN2L protein is associated with multiple disease processes. For example, it is associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease. In addition, ATXN2L protein may also be related to the occurrence and progression of malignant tumors such as breast cancer and lung cancer.

What are the biological functions of ATXN2L protein? 05/08/2020

ATXN2L protein has multiple functions in cells. It is involved in the regulation of mRNA translation, RNA transport and cell adhesion, and may also play a role in the regulation of neural development and synaptic function.

What are the structural features of the ATXN2L protein? 04/25/2020

It contains multiple conserved domains, the most prominent of which is RNA recognition motifs (RRMs). These domains may be related to their involvement in RNA recognition and binding functions.

In which tissues is ATXN2L protein highly expressed? 01/31/2020

ATXN2L protein is expressed in several tissues, but its expression is higher in the nervous system. In addition, ATXN2L expression was also detected in liver, lung, heart and other tissues.

How is ATXN2L protein associated with ALS? 05/13/2019

ATXN2L gene mutations have been found to be associated with ALS. Several specific ATXN2L mutations have been implicated in the pathogenesis of familial and sporadic ALS. These mutations may lead to the abnormal expression or function of ATXN2L protein, and then affect the normal function of nerve cells.

Customer Reviews (3)

Write a review
Reviews
04/03/2022

    The stability of ATXN2L means that we can store it and use it at any time without fear of its inactivation or deterioration.

    02/10/2020

      ATXN2L significantly improved the reproducibility of Western blotting.

      08/08/2019

        The purity of ATXN2L is very high, which can ensure the safety of the experiment and also avoid unnecessary risks.

        Ask a Question for All ATXN2L Products

        Required fields are marked with *

        My Review for All ATXN2L Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends