Recombinant Human BCCIP Protein, MYC/DDK-tagged

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Recombinant Human BCCIP Protein, MYC/DDK-tagged

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Cat.No. : BCCIP-2365H
Product Overview : Recombinant human BCCIP protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 35.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : BCCIP BRCA2 and CDKN1A interacting protein [ Homo sapiens ]
Official Symbol : BCCIP
Synonyms : TOK-1; TOK1
Gene ID : 56647
mRNA Refseq : NM_016567
Protein Refseq : NP_057651
MIM : 611883
UniProt ID : Q9P287

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