- Human(10)
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- Rhesus Macaque(1)
- Zebrafish(1)
Recombinant Human BCCIP Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | BCCIP-4365H |
| Product Overview : | BCCIP MS Standard C13 and N15-labeled recombinant protein (NP_510868) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 36.1 kDa |
| AA Sequence : | MASRSKRRAV ESGVPQPPDP PVQRDEEEEK EVENEDEDDD DSDKEKDEED EVIDEEVNIE FEAYSLSDND YDGIKKLLQQ LFLKAPVNTA ELTDLLIQQN HIGSVIKQTD VSEDSNDDMD EDEVFGFISL LNLTERKGTQ CVEQIQELVL RFCEKNCEKS MVEQLDKFLN DTTKPVGLLL SERFINVPPQ IALPMYQQLQ KELAGAHRTN KPCGKCYFYL LISKTFVEAE KNNSKKKPSN KKKAALMFAN AEEEFFYEKA ILKFNYSVQE ESDTCLGGKW SFDDVPMTPL RTVMLIPGDK MNEIMDKLKE YLSVTRTRPL EQKLISEEDL AANDILDYKD DDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | BCCIP BRCA2 and CDKN1A interacting protein [ Homo sapiens (human) ] |
| Official Symbol : | BCCIP |
| Synonyms : | BCCIP; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BCCIPalpha; TOK 1; BCCIPbeta; TOK-1beta; TOK-1alpha; protein TOK-1; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; BRCA2 and Cip1/p21 interacting protein; TOK1; TOK-1; |
| Gene ID : | 56647 |
| mRNA Refseq : | NM_078468 |
| Protein Refseq : | NP_510868 |
| MIM : | 611883 |
| UniProt ID : | Q9P287 |
◆ Recombinant Protein
| Bccip-1845M | Recombinant Mouse Bccip Protein, Myc/DDK-tagged | +Inquiry |
| BCCIP-2365H | Recombinant Human BCCIP Protein, MYC/DDK-tagged | +Inquiry |
| BCCIP-255H | Recombinant Human BCCIP, His-tagged | +Inquiry |
| BCCIP-623H | Recombinant Human BCCIP Protein | +Inquiry |
| BCCIP-2156Z | Recombinant Zebrafish BCCIP | +Inquiry |
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◆ Lysates
| BCCIP-001HCL | Recombinant Human BCCIP cell lysate | +Inquiry |
| BCCIP-002HCL | Recombinant Human BCCIP cell lysate | +Inquiry |
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